University of Tasmania
Browse

File(s) under permanent embargo

Forgetting fear associations through tES: which memory process might be critical?

journal contribution
posted on 2023-05-22, 00:24 authored by Vicario, CM, Nitsche, MA, Kim FelminghamKim Felmingham
© The Author(s) 2017. We read with interest the article by Abend and colleagues1 titled 'Modulation of fear extinction processes using transcranial electrical stimulation', which adds relevant insights to the extremely limited literature on the effect of non-invasive brain stimulation on fear extinction mechanisms. Given the interest in using brain stimulation for treatment of anxiety disorders and post-traumatic stress disorder, research examining the impact of non-invasive brain stimulation on mechanisms involved in the maintenance and treatment of these disorders is critical. In their study, Abend and colleagues examined the effects of two different types of non-invasive transcranial electrical stimulation (tES; that is, direct current (DC) and alternating current (AC) stimulation) on fear extinction processes in healthy humans to assess a potential relevance/application of these protocols in therapeutic context. Thus, the authors decided to test three separate groups of participants (that is, DC, AC and Sham stimulation) by targeting the medial prefrontal cortex, which is known to mediate fear extinction mechanisms (for example, Milad and Quirk2), in a 3-day protocol. On the basis of previous research, they expected that excitability-enhancing anodal tDCS over the ventromedial prefrontal cortex would improve extinction, most probably via activation of GABAergic neurons of the amygdala,3 and that low-frequency tACS during extinction might reduce fear memory consolidation via long-term depression-like effects. Skin conductance and self-report responses were examined to assess the effect of the provided treatments in fear extinction.

History

Publication title

Translational psychiatry

Volume

7

Pagination

e1046

ISSN

2158-3188

Department/School

School of Psychological Sciences

Publisher

Nature Pub. Group

Place of publication

United States

Repository Status

  • Restricted

Socio-economic Objectives

Expanding knowledge in psychology

Usage metrics

    University Of Tasmania

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC