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Pressurized hot water extraction as a viable bioprospecting tool: isolation of coumarin natural products from previously unexamined Correa (Rutaceae) species
journal contribution
posted on 2023-05-19, 03:23 authored by Bianca DeansBianca Deans, Just, J, Chhetri, J, Burt, LK, James Smith, Nathan KilahNathan Kilah, de Salas, M, Nuri GuvenNuri Guven, Alexander BissemberAlexander Bissember, Jason SmithJason SmithThe potential of a recently developed pressurized hot water extraction (PHWE) method employing an unmodified household espresso machine to facilitate rapid bioprospecting was investigated. A survey of some 16 Australian native plant species identified three Correa (Rutaceae) species containing significant quantities of coumarin natural products. As part of this study, seselin, (+)-epoxysuberosin, alosin, (–)-meranzin and heraclenin were isolated and, subsequently, used to synthesize the related natural products (+)-trachypleuranin A and (–)-yuehgesin B. In addition, seselin, (+)-epoxysuberosin, alosin, and (–)-meranzin were found to inhibit NQO1 activity. Interestingly, (–)-meranzin showed inhibitory activity comparable to the known potent NQO1 inhibitor dicoumarol.
History
Publication title
ChemistrySelectIssue
8Pagination
2439-2443ISSN
2365-6549Department/School
School of Natural SciencesPublisher
Wiley - V C H Verlag GmbH & Co. KGaAPlace of publication
GermanyRights statement
Copyright 2017 Wiley-VCH Verlag GmbH & Co. KGaA, WeinheimRepository Status
- Restricted