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Pressurized hot water extraction as a viable bioprospecting tool: isolation of coumarin natural products from previously unexamined Correa (Rutaceae) species

Citation

Deans, BJ and Just, J and Chhetri, J and Burt, LK and Smith, JN and Kilah, NL and de Salas, M and Gueven, N and Bissember, AC and Smith, JA, Pressurized hot water extraction as a viable bioprospecting tool: isolation of coumarin natural products from previously unexamined Correa (Rutaceae) species, ChemistrySelect, 2, (8) pp. 2439-2443. ISSN 2365-6549 (2017) [Refereed Article]

Copyright Statement

Copyright 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim

DOI: doi:10.1002/slct.201602006

Abstract

The potential of a recently developed pressurized hot water extraction (PHWE) method employing an unmodified household espresso machine to facilitate rapid bioprospecting was investigated. A survey of some 16 Australian native plant species identified three Correa (Rutaceae) species containing significant quantities of coumarin natural products. As part of this study, seselin, (+)-epoxysuberosin, alosin, ()-meranzin and heraclenin were isolated and, subsequently, used to synthesize the related natural products (+)-trachypleuranin A and ()-yuehgesin B. In addition, seselin, (+)-epoxysuberosin, alosin, and ()-meranzin were found to inhibit NQO1 activity. Interestingly, ()-meranzin showed inhibitory activity comparable to the known potent NQO1 inhibitor dicoumarol.

Item Details

Item Type:Refereed Article
Keywords:bioprospecting, coumarins, drug discovery, natural products, pressurized hot water extraction
Research Division:Chemical Sciences
Research Group:Organic Chemistry
Research Field:Organic Chemical Synthesis
Objective Division:Expanding Knowledge
Objective Group:Expanding Knowledge
Objective Field:Expanding Knowledge in the Chemical Sciences
Author:Deans, BJ (Miss Bianca Deans)
Author:Just, J (Mr Jeremy Just)
Author:Chhetri, J (Ms Jamuna Chhetri)
Author:Burt, LK (Mr Liam Burt)
Author:Smith, JN (Mr James Smith)
Author:Kilah, NL (Dr Nathan Kilah)
Author:Gueven, N (Associate Professor Nuri Gueven)
Author:Bissember, AC (Dr Alex Bissember)
Author:Smith, JA (Associate Professor Jason Smith)
ID Code:115469
Year Published:2017
Deposited By:Chemistry
Deposited On:2017-03-27
Last Modified:2017-11-21
Downloads:0

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