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Pressurized hot water extraction as a viable bioprospecting tool: isolation of coumarin natural products from previously unexamined Correa (Rutaceae) species
Citation
Deans, BJ and Just, J and Chhetri, J and Burt, LK and Smith, JN and Kilah, NL and de Salas, M and Guven, N and Bissember, AC and Smith, JA, Pressurized hot water extraction as a viable bioprospecting tool: isolation of coumarin natural products from previously unexamined Correa (Rutaceae) species, ChemistrySelect, 2, (8) pp. 2439-2443. ISSN 2365-6549 (2017) [Refereed Article]
Copyright Statement
Copyright 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
DOI: doi:10.1002/slct.201602006
Abstract
The potential of a recently developed pressurized hot water extraction (PHWE) method employing an unmodified household espresso machine to facilitate rapid bioprospecting was investigated. A survey of some 16 Australian native plant species identified three Correa (Rutaceae) species containing significant quantities of coumarin natural products. As part of this study, seselin, (+)-epoxysuberosin, alosin, (–)-meranzin and heraclenin were isolated and, subsequently, used to synthesize the related natural products (+)-trachypleuranin A and (–)-yuehgesin B. In addition, seselin, (+)-epoxysuberosin, alosin, and (–)-meranzin were found to inhibit NQO1 activity. Interestingly, (–)-meranzin showed inhibitory activity comparable to the known potent NQO1 inhibitor dicoumarol.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Keywords: | bioprospecting, coumarins, drug discovery, natural products, pressurized hot water extraction |
| Research Division: | Chemical Sciences |
| Research Group: | Organic chemistry |
| Research Field: | Organic chemical synthesis |
| Objective Division: | Expanding Knowledge |
| Objective Group: | Expanding knowledge |
| Objective Field: | Expanding knowledge in the chemical sciences |
| UTAS Author: | Deans, BJ (Dr Bianca Deans) |
| UTAS Author: | Just, J (Mr Jeremy Just) |
| UTAS Author: | Chhetri, J (Ms Jamuna Chhetri) |
| UTAS Author: | Burt, LK (Mr Liam Burt) |
| UTAS Author: | Smith, JN (Mr James Smith) |
| UTAS Author: | Kilah, NL (Dr Nathan Kilah) |
| UTAS Author: | Guven, N (Dr Nuri Guven) |
| UTAS Author: | Bissember, AC (Associate Professor Alex Bissember) |
| UTAS Author: | Smith, JA (Professor Jason Smith) |
| ID Code: | 115469 |
| Year Published: | 2017 |
| Web of Science® Times Cited: | 12 |
| Deposited By: | Chemistry |
| Deposited On: | 2017-03-27 |
| Last Modified: | 2022-08-19 |
| Downloads: | 0 |
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