eCite Digital Repository
The States of Pluripotency: Pluripotent Lineage Development in the Embryo and in the Dish
Citation
Rathjen, J, The States of Pluripotency: Pluripotent Lineage Development in the Embryo and in the Dish, ISRN Stem Cells Article 208067. ISSN 2090-8792 (2014) [Refereed Article]
Abstract
The pluripotent cell lineage of the embryo comprises a series of temporally and functionally distinct intermediary cell states, the
epiblast precursor cell of the newly formed blastocyst, the epiblast population of the inner cell mass, and the early and late epiblast
of the postimplantation embryo, referred to here as early and late primitive ectoderm. Pluripotent cell populations representative of
the embryonic populations can be formed in culture. Although multiple pluripotent cell states are now recognised, little is known
about the signals and pathways that progress cells from the epiblast precursor cell to the late primitive ectoderm in the embryo
or in culture. The characterisation of cell states is most advanced in mouse where conditions for culturing distinct pluripotent cell
states are well established and embryonic material is accessible. This review will focus on the pluripotent cell states present during
embryonic development in the mouse and what is known of the mechanisms that regulate the progression of the lineage from
the epiblast precursor cell and the ground state of pluripotency to the late primitive ectoderm present immediately prior to cell
differentiation.
Item Details
Item Type: | Refereed Article |
---|---|
Keywords: | pluripotency, embryo |
Research Division: | Biological Sciences |
Research Group: | Biochemistry and cell biology |
Research Field: | Cell development, proliferation and death |
Objective Division: | Expanding Knowledge |
Objective Group: | Expanding knowledge |
Objective Field: | Expanding knowledge in the biological sciences |
UTAS Author: | Rathjen, J (Dr Joy Rathjen) |
ID Code: | 115396 |
Year Published: | 2014 |
Deposited By: | Medicine |
Deposited On: | 2017-03-22 |
Last Modified: | 2017-03-22 |
Downloads: | 0 |
Repository Staff Only: item control page