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A computational mechanistic investigation into the reduction of Pt(IV) prodrugs with two axial chlorides by biological reductants
journal contribution
posted on 2023-05-19, 03:11 authored by Ejehi, Z, Alireza AriafardAlireza AriafardIt is widely reported that the Pt(iv) prodrugs with two axial chlorido ligands are reduced by biological reductants via a chloride-bridged inner-sphere mechanism. By contrast, in this contribution, we demonstrate that although this approach might be true for the reductants with sulphur donors, the reduction by ascorbates preferentially occurs via an outer sphere mechanism.
History
Publication title
Chemical CommunicationsVolume
53Issue
8Pagination
1413-1416ISSN
1359-7345Department/School
School of Natural SciencesPublisher
Royal Soc ChemistryPlace of publication
Thomas Graham House, Science Park, Milton Rd, Cambridge, England, Cambs, Cb4 0WfRights statement
Copyright 2017 The Royal Society of ChemistryRepository Status
- Restricted