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A computational mechanistic investigation into the reduction of Pt(IV) prodrugs with two axial chlorides by biological reductants

Citation

Ejehi, Z and Ariafard, A, A computational mechanistic investigation into the reduction of Pt(IV) prodrugs with two axial chlorides by biological reductants, Chemical Communications, 53, (8) pp. 1413-1416. ISSN 1359-7345 (2017) [Refereed Article]

Copyright Statement

Copyright 2017 The Royal Society of Chemistry

DOI: doi:10.1039/c6cc07834f

Abstract

It is widely reported that the Pt(iv) prodrugs with two axial chlorido ligands are reduced by biological reductants via a chloride-bridged inner-sphere mechanism. By contrast, in this contribution, we demonstrate that although this approach might be true for the reductants with sulphur donors, the reduction by ascorbates preferentially occurs via an outer sphere mechanism.

Item Details

Item Type:Refereed Article
Keywords:Pt(IV) prodrugs, reduction, biological reductants, density functional theory (DFT)
Research Division:Chemical Sciences
Research Group:Inorganic Chemistry
Research Field:Bioinorganic Chemistry
Objective Division:Expanding Knowledge
Objective Group:Expanding Knowledge
Objective Field:Expanding Knowledge in the Chemical Sciences
Author:Ariafard, A (Associate Professor Alireza Ariafard)
ID Code:115332
Year Published:2017
Deposited By:Chemistry
Deposited On:2017-03-17
Last Modified:2017-05-04
Downloads:0

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