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Mechanisms of action of green tea catechins, with a focus on ischemia-induced neurodegeneration
Citation
Sutherland, BA and Rahman, RM and Appleton, I, Mechanisms of action of green tea catechins, with a focus on ischemia-induced neurodegeneration, Journal of Nutritional Biochemistry, 17, (5) pp. 291 - 306. ISSN 0955-2863 (2006) [Refereed Article]
Copyright Statement
Copyright 2006 Elsevier Inc.
DOI: doi:10.1016/j.jnutbio.2005.10.005
Abstract
Catechins are dietary polyphenolic compounds associated with a wide variety of beneficial health effects in vitro, in vivo and clinically.
These therapeutic properties have long been attributed to the catechins’ antioxidant and free radical scavenging effects. Emerging evidence
has shown that catechins and their metabolites have many additional mechanisms of action by affecting numerous sites, potentiating
endogenous antioxidants and eliciting dual actions during oxidative stress, ischemia and inflammation. Catechins have proven to modulate
apoptosis at various points in the sequence, including altering expression of anti- and proapoptotic genes. Their anti-inflammatory effects are
activated through a variety of different mechanisms, including modulation of nitric oxide synthase isoforms. Catechins’ actions of attenuating
oxidative stress and the inflammatory response may, in part, account for their confirmed neuroprotective capabilities following cerebral
ischemia. The versatility of the mechanisms of action of catechins increases their therapeutic potential as interventions for numerous clinical
disorders. However, more epidemiological and clinical studies need to be undertaken for their efficacy to be fully elucidated.
Item Details
Item Type: | Refereed Article |
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Keywords: | catechins, cerebral ischemia, inflammation, nitric oxide synthase, antioxidant |
Research Division: | Biomedical and Clinical Sciences |
Research Group: | Neurosciences |
Research Field: | Central nervous system |
Objective Division: | Expanding Knowledge |
Objective Group: | Expanding knowledge |
Objective Field: | Expanding knowledge in the health sciences |
UTAS Author: | Sutherland, BA (Associate Professor Brad Sutherland) |
ID Code: | 115306 |
Year Published: | 2006 |
Web of Science® Times Cited: | 228 |
Deposited By: | Office of the School of Medicine |
Deposited On: | 2017-03-15 |
Last Modified: | 2017-06-06 |
Downloads: | 0 |
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