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Mechanisms of action of green tea catechins, with a focus on ischemia-induced neurodegeneration


Sutherland, BA and Rahman, RM and Appleton, I, Mechanisms of action of green tea catechins, with a focus on ischemia-induced neurodegeneration, Journal of Nutritional Biochemistry, 17, (5) pp. 291 - 306. ISSN 0955-2863 (2006) [Refereed Article]

Copyright Statement

Copyright 2006 Elsevier Inc.

DOI: doi:10.1016/j.jnutbio.2005.10.005


Catechins are dietary polyphenolic compounds associated with a wide variety of beneficial health effects in vitro, in vivo and clinically. These therapeutic properties have long been attributed to the catechinsí antioxidant and free radical scavenging effects. Emerging evidence has shown that catechins and their metabolites have many additional mechanisms of action by affecting numerous sites, potentiating endogenous antioxidants and eliciting dual actions during oxidative stress, ischemia and inflammation. Catechins have proven to modulate apoptosis at various points in the sequence, including altering expression of anti- and proapoptotic genes. Their anti-inflammatory effects are activated through a variety of different mechanisms, including modulation of nitric oxide synthase isoforms. Catechinsí actions of attenuating oxidative stress and the inflammatory response may, in part, account for their confirmed neuroprotective capabilities following cerebral ischemia. The versatility of the mechanisms of action of catechins increases their therapeutic potential as interventions for numerous clinical disorders. However, more epidemiological and clinical studies need to be undertaken for their efficacy to be fully elucidated.

Item Details

Item Type:Refereed Article
Keywords:catechins, cerebral ischemia, inflammation, nitric oxide synthase, antioxidant
Research Division:Biomedical and Clinical Sciences
Research Group:Neurosciences
Research Field:Central nervous system
Objective Division:Expanding Knowledge
Objective Group:Expanding knowledge
Objective Field:Expanding knowledge in the health sciences
UTAS Author:Sutherland, BA (Associate Professor Brad Sutherland)
ID Code:115306
Year Published:2006
Web of Science® Times Cited:228
Deposited By:Office of the School of Medicine
Deposited On:2017-03-15
Last Modified:2017-06-06

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