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The transient intraluminal filament middle cerebral artery occlusion model as a model of endovascular thrombectomy in stroke

journal contribution
posted on 2023-05-19, 03:08 authored by Brad SutherlandBrad Sutherland, Neuhaus, AA, Couch, Y, Balami, JS, DeLuca, GC, Hadley, G, Harris, SL, Grey, AN, Buchan, AM
The clinical relevance of the transient intraluminal filament model of middle cerebral artery occlusion (tMCAO) has been questioned due to distinct cerebral blood flow profiles upon reperfusion between tMCAO (abrupt reperfusion) and alteplase treatment (gradual reperfusion), resulting in differing pathophysiologies. Positive results from recent endovascular thrombectomy trials, where the occluding clot is mechanically removed, could revolutionize stroke treatment. The rapid cerebral blood flow restoration in both tMCAO and endovascular thrombectomy provides clinical relevance for this pre-clinical model. Any future clinical trials of neuroprotective agents as adjuncts to endovascular thrombectomy should consider tMCAO as the model of choice to determine pre-clinical efficacy.

History

Publication title

Journal of cerebral blood flow and metabolism

Volume

36

Pagination

363-369

ISSN

0271-678X

Department/School

Tasmanian School of Medicine

Publisher

SAGE Publications

Place of publication

United States

Rights statement

Copyright 2015 the Author(s)

Repository Status

  • Restricted

Socio-economic Objectives

Expanding knowledge in the health sciences

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