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The transient intraluminal filament middle cerebral artery occlusion model as a model of endovascular thrombectomy in stroke
journal contribution
posted on 2023-05-19, 03:08 authored by Brad SutherlandBrad Sutherland, Neuhaus, AA, Couch, Y, Balami, JS, DeLuca, GC, Hadley, G, Harris, SL, Grey, AN, Buchan, AMThe clinical relevance of the transient intraluminal filament model of middle cerebral artery occlusion (tMCAO) has been questioned due to distinct cerebral blood flow profiles upon reperfusion between tMCAO (abrupt reperfusion) and alteplase treatment (gradual reperfusion), resulting in differing pathophysiologies. Positive results from recent endovascular thrombectomy trials, where the occluding clot is mechanically removed, could revolutionize stroke treatment. The rapid cerebral blood flow restoration in both tMCAO and endovascular thrombectomy provides clinical relevance for this pre-clinical model. Any future clinical trials of neuroprotective agents as adjuncts to endovascular thrombectomy should consider tMCAO as the model of choice to determine pre-clinical efficacy.
History
Publication title
Journal of cerebral blood flow and metabolismVolume
36Pagination
363-369ISSN
0271-678XDepartment/School
Tasmanian School of MedicinePublisher
SAGE PublicationsPlace of publication
United StatesRights statement
Copyright 2015 the Author(s)Repository Status
- Restricted