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Neuroprotection for Stroke: Current Status and Future Perspectives

Citation

Minnerup, J and Sutherland, BA and Buchan, AM and Kleinschnitz, C, Neuroprotection for Stroke: Current Status and Future Perspectives, International journal of molecular sciences, 13, (9) pp. 11753-11772. ISSN 1422-0067 (2012) [Refereed Article]


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Copyright 2012 The Authors Licensed under Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported (CC BY-NC-SA 3.0) https://creativecommons.org/licenses/by-nc-sa/3.0/

DOI: doi:10.3390/ijms130911753

Abstract

Neuroprotection aims to prevent salvageable neurons from dying. Despite showing efficacy in experimental stroke studies, the concept of neuroprotection has failed in clinical trials. Reasons for the translational difficulties include a lack of methodological agreement between preclinical and clinical studies and the heterogeneity of stroke in humans compared to homogeneous strokes in animal models. Even when the international recommendations for preclinical stroke research, the Stroke Academic Industry Roundtable (STAIR) criteria, were followed, we have still seen limited success in the clinic, examples being NXY-059 and haematopoietic growth factors which fulfilled nearly all the STAIR criteria. However, there are a number of neuroprotective treatments under investigation in clinical trials such as hypothermia and ebselen. Moreover, promising neuroprotective treatments based on a deeper understanding of the complex pathophysiology of ischemic stroke such as inhibitors of NADPH oxidases and PSD-95 are currently evaluated in preclinical studies. Further concepts to improve translation include the investigation of neuroprotectants in multicenter preclinical Phase III-type studies, improved animal models, and close alignment between clinical trial and preclinical methodologies. Future successful translation will require both new concepts for preclinical testing and innovative approaches based on mechanistic insights into the ischemic cascade.

Item Details

Item Type:Refereed Article
Keywords:neuroprotection, ischemic stroke, translation, STAIR, ischemic cascade
Research Division:Medical and Health Sciences
Research Group:Neurosciences
Research Field:Central Nervous System
Objective Division:Expanding Knowledge
Objective Group:Expanding Knowledge
Objective Field:Expanding Knowledge in the Medical and Health Sciences
Author:Sutherland, BA (Dr Brad Sutherland)
ID Code:115147
Year Published:2012
Web of Science® Times Cited:56
Deposited By:Office of the School of Medicine
Deposited On:2017-03-08
Last Modified:2017-11-06
Downloads:8 View Download Statistics

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