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Lipidomics Reveals Associations of Phospholipids With Obesity and Insulin Resistance in Young Adults
Citation
Rauschert, S and Uhl, O and Koletzko, B and Kirchberg, F and Mori, TA and Huang, R-C and Beilin, LJ and Hellmuth, C and Oddy, WH, Lipidomics Reveals Associations of Phospholipids With Obesity and Insulin Resistance in Young Adults, Journal of Clinical Endocrinology and Metabolism, 101, (3) pp. 871-879. ISSN 0021-972X (2016) [Refereed Article]
Copyright Statement
Copyright © 2016 by the Endocrine Society
Abstract
OBJECTIVE: This study aimed to identify the lipidomic biomarkers associated with obesity and IR using plasma samples from a population-based cohort of young adults.
DESIGN AND SETTING: The Western Australian Pregnancy Cohort (Raine) study enrolled 2900 pregnant women from 1989 to 1991. The 20-year follow-up was conducted between March 2010 and April 2012. Participants and Samples: Plasma samples from 1176 subjects aged 20 years were analyzed using mass spectrometry-based metabolomics.
MAIN OUTCOME MEASURES: Associations of analytes with markers of obesity and IR including body mass index, waist circumference, homeostasis model assessment (HOMA-IR), and insulin were examined. Analyses were stratified by body mass index and adjusted for lifestyle and other factors.
RESULTS: Waist circumference was positively associated with seven sphingomyelins and five diacylphosphatidylcholines and negatively associated with two lysophosphatidylcholines. HOMA-IR was negatively associated with two diacylphosphatidylcholines and positively with one lysophosphatidylcholine and one diacylphosphatidylcholine. No significant association was found in the obese/overweight group of the HOMA-IR model. In the normal-weight group, one lysophosphatidylcholine was increased.
CONCLUSION: A possible discriminative effect of sphingomyelins, particularly those with two double bonds, and lysophosphatidylcholines was identified between subjects with normal weight and obesity independent of low-density lipoprotein cholesterol and high-density lipoprotein cholesterol concentrations. Our results suggest weight status-dependent mechanisms for the development of IR with lysophosphatidylcholine C14:0 as a key metabolite in nonobese IR.
Item Details
Item Type: | Refereed Article |
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Research Division: | Biomedical and Clinical Sciences |
Research Group: | Nutrition and dietetics |
Research Field: | Nutrition and dietetics not elsewhere classified |
Objective Division: | Health |
Objective Group: | Public health (excl. specific population health) |
Objective Field: | Nutrition |
UTAS Author: | Oddy, WH (Professor Wendy Oddy) |
ID Code: | 114910 |
Year Published: | 2016 |
Web of Science® Times Cited: | 71 |
Deposited By: | Menzies Institute for Medical Research |
Deposited On: | 2017-03-02 |
Last Modified: | 2017-11-03 |
Downloads: | 0 |
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