Rauschert, S and Uhl, O and Koletzko, B and Kirchberg, F and Mori, TA and Huang, R-C and Beilin, LJ and Hellmuth, C and Oddy, WH, Lipidomics Reveals Associations of Phospholipids With Obesity and Insulin Resistance in Young Adults, Journal of Clinical Endocrinology and Metabolism, 101, (3) pp. 871-879. ISSN 0021-972X (2016) [Refereed Article]
Copyright © 2016 by the Endocrine Society
OBJECTIVE: This study aimed to identify the lipidomic biomarkers associated with obesity and IR using plasma samples from a population-based cohort of young adults.
DESIGN AND SETTING: The Western Australian Pregnancy Cohort (Raine) study enrolled 2900 pregnant women from 1989 to 1991. The 20-year follow-up was conducted between March 2010 and April 2012. Participants and Samples: Plasma samples from 1176 subjects aged 20 years were analyzed using mass spectrometry-based metabolomics.
MAIN OUTCOME MEASURES: Associations of analytes with markers of obesity and IR including body mass index, waist circumference, homeostasis model assessment (HOMA-IR), and insulin were examined. Analyses were stratified by body mass index and adjusted for lifestyle and other factors.
RESULTS: Waist circumference was positively associated with seven sphingomyelins and five diacylphosphatidylcholines and negatively associated with two lysophosphatidylcholines. HOMA-IR was negatively associated with two diacylphosphatidylcholines and positively with one lysophosphatidylcholine and one diacylphosphatidylcholine. No significant association was found in the obese/overweight group of the HOMA-IR model. In the normal-weight group, one lysophosphatidylcholine was increased.
CONCLUSION: A possible discriminative effect of sphingomyelins, particularly those with two double bonds, and lysophosphatidylcholines was identified between subjects with normal weight and obesity independent of low-density lipoprotein cholesterol and high-density lipoprotein cholesterol concentrations. Our results suggest weight status-dependent mechanisms for the development of IR with lysophosphatidylcholine C14:0 as a key metabolite in nonobese IR.
|Item Type:||Refereed Article|
|Research Division:||Medical and Health Sciences|
|Research Group:||Nutrition and Dietetics|
|Research Field:||Nutrition and Dietetics not elsewhere classified|
|Objective Group:||Public Health (excl. Specific Population Health)|
|Author:||Oddy, WH (Professor Wendy Oddy)|
|Web of Science® Times Cited:||27|
|Deposited By:||Menzies Institute for Medical Research|
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