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Hip shape as a predictor of osteoarthritis progression in a prospective population cohort

Citation

Ahedi, HG and Aspden, RM and Blizzard, LC and Saunders, FR and Cicuttini, FM and Aitken, DA and Jones, G and Gregory, JS, Hip shape as a predictor of osteoarthritis progression in a prospective population cohort, Arthritis Care & Research, 69, (10) pp. 1566-1573. ISSN 2151-4658 (2017) [Refereed Article]


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Copyright Statement

Copyright 2016 American College of Rheumatology

DOI: doi:10.1002/acr.23166

Abstract

OBJECTIVE: Hip morphology plays a significant role in the incidence and progression of hip osteoarthritis (OA). We hypothesized that hip shape would also associate with other key factors and tested this in a longitudinal community-based cohort combining radiographic, MRI, DXA, and clinical data.

METHODS: Baseline dual-energy X-ray absorptiometry (DXA) images of the left hip of 831 subjects from the Tasmanian Older Adult Cohort (TASOAC) were analyzed using an 85-point statistical shape model. Hip pain was assessed by WOMAC (Western Ontario and McMaster Universities Osteoarthritis Index) and muscle strength was measured by a dynamometer. Hip structural changes were assessed using MRI and Radiographic OA (ROA) using plain radiographs.

RESULTS: Six shape modes described 68% of shape variation. At baseline, modes 1, 2, 4 and 6 were associated with hip ROA, modes 1, 3, 4 and 6 correlated with hip cartilage volume and all except mode 2 with muscle strength. Higher mode 1, and lower mode 3 and 6 scores at baseline predicted hip pain at follow-up and higher mode 1 and mode 2 scores were associated with hip effusion-synovitis. Greater scores for mode 2 (decreasing acetabular coverage) and lower mode 4 (non-spherical femoral head) at baseline predicted 10-year total hip replacement (THR); while mode 4 alone correlated with bone marrow lesions (BMLs), effusion-synovitis, and increased cartilage signal.

CONCLUSIONS: Hip shape is associated with ROA, THR, hip pain, effusion-synovitis, BMLs, muscle strength and hip structural changes. These data suggest that different shape modes reflect multiple facets of hip osteoarthritis. This article is protected by copyright. All rights reserved.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Clinical Sciences
Research Field:Rheumatology and Arthritis
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Skeletal System and Disorders (incl. Arthritis)
Author:Ahedi, HG (Ms Harbeer Ahedi)
Author:Blizzard, LC (Associate Professor Leigh Blizzard)
Author:Aitken, DA (Dr Dawn Aitken)
Author:Jones, G (Professor Graeme Jones)
ID Code:114862
Year Published:2017 (online first 2016)
Web of Science® Times Cited:20
Deposited By:Menzies Institute for Medical Research
Deposited On:2017-03-01
Last Modified:2017-11-01
Downloads:0

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