Ahedi, HG and Aspden, RM and Blizzard, LC and Saunders, FR and Cicuttini, FM and Aitken, DA and Jones, G and Gregory, JS, Hip shape as a predictor of osteoarthritis progression in a prospective population cohort, Arthritis Care & Research, 69, (10) pp. 1566-1573. ISSN 2151-4658 (2017) [Refereed Article]
Copyright 2016 American College of Rheumatology
METHODS: Baseline dual-energy X-ray absorptiometry (DXA) images of the left hip of 831 subjects from the Tasmanian Older Adult Cohort (TASOAC) were analyzed using an 85-point statistical shape model. Hip pain was assessed by WOMAC (Western Ontario and McMaster Universities Osteoarthritis Index) and muscle strength was measured by a dynamometer. Hip structural changes were assessed using MRI and Radiographic OA (ROA) using plain radiographs.
RESULTS: Six shape modes described 68% of shape variation. At baseline, modes 1, 2, 4 and 6 were associated with hip ROA, modes 1, 3, 4 and 6 correlated with hip cartilage volume and all except mode 2 with muscle strength. Higher mode 1, and lower mode 3 and 6 scores at baseline predicted hip pain at follow-up and higher mode 1 and mode 2 scores were associated with hip effusion-synovitis. Greater scores for mode 2 (decreasing acetabular coverage) and lower mode 4 (non-spherical femoral head) at baseline predicted 10-year total hip replacement (THR); while mode 4 alone correlated with bone marrow lesions (BMLs), effusion-synovitis, and increased cartilage signal.
CONCLUSIONS: Hip shape is associated with ROA, THR, hip pain, effusion-synovitis, BMLs, muscle strength and hip structural changes. These data suggest that different shape modes reflect multiple facets of hip osteoarthritis. This article is protected by copyright. All rights reserved.
|Item Type:||Refereed Article|
|Research Division:||Medical and Health Sciences|
|Research Group:||Clinical Sciences|
|Research Field:||Rheumatology and Arthritis|
|Objective Group:||Clinical Health (Organs, Diseases and Abnormal Conditions)|
|Objective Field:||Skeletal System and Disorders (incl. Arthritis)|
|Author:||Ahedi, HG (Ms Harbeer Ahedi)|
|Author:||Blizzard, LC (Professor Leigh Blizzard)|
|Author:||Aitken, DA (Dr Dawn Aitken)|
|Author:||Jones, G (Professor Graeme Jones)|
|Year Published:||2017 (online first 2016)|
|Web of Science® Times Cited:||58|
|Deposited By:||Menzies Institute for Medical Research|
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