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Farnesylation mediates brassinosteroid biosynthesis to regulate abscisic acid responses


Northey, JGB and Liang, S and Jamshed, M and Deb, S and Foo, E and Reid, JB and McCourt, P and Samuel, MA, Farnesylation mediates brassinosteroid biosynthesis to regulate abscisic acid responses, Nature Plants, 2, (8) Article 16114. ISSN 2055-026X (2016) [Refereed Article]

Copyright Statement

Copyright 2016 Nature plants

DOI: doi:10.1038/NPLANTS.2016.114


Protein farnesylation is a post-translational modification involving the addition of a 15-carbon farnesyl isoprenoid to the carboxy terminus of select proteins13. Although the roles of this lipid modification are clear in both fungal and animal signalling, many of the mechanistic functions of farnesylation in plant signalling are still unknown. Here, we show that CYP85A2, the cytochrome P450 enzyme that performs the last step in brassinosteroid biosynthesis (conversion of castasterone to brassinolide)4, must be farnesylated to function in Arabidopsis. Loss of either CYP85A2 or CYP85A2 farnesylation results in reduced brassinolide accumulation and increased plant responsiveness to the hormone abscisic acid (ABA) and overall drought tolerance, explaining previous observations5. This result not only directly links farnesylation to brassinosteroid biosynthesis but also suggests new strategies to maintain crop yield under challenging climatic conditions.

Item Details

Item Type:Refereed Article
Keywords:brassinosteroid, drought
Research Division:Biological Sciences
Research Group:Plant biology
Research Field:Plant physiology
Objective Division:Plant Production and Plant Primary Products
Objective Group:Environmentally sustainable plant production
Objective Field:Environmentally sustainable plant production not elsewhere classified
UTAS Author:Foo, E (Associate Professor Eloise Foo)
UTAS Author:Reid, JB (Professor Jim Reid)
ID Code:114788
Year Published:2016
Funding Support:Australian Research Council (FT140100770)
Web of Science® Times Cited:62
Deposited By:Plant Science
Deposited On:2017-02-27
Last Modified:2018-07-11

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