Pathan, F and D'Elia, N and Nolan, MT and Marwick, TH and Negishi, K, Normal ranges of left atrial strain by speckle-tracking echocardiography: A systematic review and meta-analysis, Journal of the American Society of Echocardiography, 30, (1) pp. 59-70. ISSN 0894-7317 (2017) [Refereed Article]
Copyright 2016 by the American Society of Echocardiography
Methods: The authors searched the PubMed, Embase, and Scopus databases for the key terms "left atrial/atrial/atrium" and "strain/function/deformation/stiffness" and "speckle tracking/Velocity Vector Imaging/edge tracking." Studies of global left atrial function using speckle-tracking were selected if they involved >30 normal or healthy participants without any cardiac risk factors. Normal ranges for reservoir strain, conduit strain, and contractile strain were computed using a random-effects model. Meta-regression and subgroup analysis was performed to explore between-study heterogeneity.
Results: Forty studies (2,542 healthy subjects) satisfied the inclusion criteria. Meta-analysis revealed a normal reference range for reservoir strain of 39% (95% CI, 38%-41%, from 40 articles), for conduit strain of 23% (95% CI, 21%-25%, from 14 articles), and for contractile strain of 17% (95% CI, 16%-19%, from 18 articles). Meta-regression identified heart rate (P = .02) and body surface area (P = .003) as contributors to this heterogeneity. Subgroup analyses revealed heterogeneity due to sample size (n > 100 vs N < 100, P = .02).
Conclusions: The normal reference ranges for the three components of left atrial function are demonstrated. The between-study heterogeneity is explained partly by heart rate, body surface area, and sample size.
|Item Type:||Refereed Article|
|Keywords:||strain, atrial, normal range, meta-analysis|
|Research Division:||Medical and Health Sciences|
|Research Group:||Cardiorespiratory Medicine and Haematology|
|Research Field:||Cardiology (incl. Cardiovascular Diseases)|
|Objective Group:||Clinical Health (Organs, Diseases and Abnormal Conditions)|
|Objective Field:||Cardiovascular System and Diseases|
|Author:||Pathan, F (Dr Faraz Pathan)|
|Author:||D'Elia, N (Mr Nic D'Elia)|
|Author:||Nolan, MT (Mr Mark Nolan)|
|Author:||Marwick, TH (Professor Tom Marwick)|
|Author:||Negishi, K (Dr Kazuaki Negishi)|
|Web of Science® Times Cited:||28|
|Deposited By:||Menzies Institute for Medical Research|
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