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Normal ranges of left atrial strain by speckle-tracking echocardiography: A systematic review and meta-analysis
Citation
Pathan, F and D'Elia, N and Nolan, MT and Marwick, TH and Negishi, K, Normal ranges of left atrial strain by speckle-tracking echocardiography: A systematic review and meta-analysis, Journal of the American Society of Echocardiography, 30, (1) pp. 59-70. ISSN 0894-7317 (2017) [Refereed Article]
Copyright Statement
Copyright 2016 by the American Society of Echocardiography
DOI: doi:10.1016/j.echo.2016.09.007
Abstract
Methods: The authors searched the PubMed, Embase, and Scopus databases for the key terms "left atrial/atrial/atrium" and "strain/function/deformation/stiffness" and "speckle tracking/Velocity Vector Imaging/edge tracking." Studies of global left atrial function using speckle-tracking were selected if they involved >30 normal or healthy participants without any cardiac risk factors. Normal ranges for reservoir strain, conduit strain, and contractile strain were computed using a random-effects model. Meta-regression and subgroup analysis was performed to explore between-study heterogeneity.
Results: Forty studies (2,542 healthy subjects) satisfied the inclusion criteria. Meta-analysis revealed a normal reference range for reservoir strain of 39% (95% CI, 38%-41%, from 40 articles), for conduit strain of 23% (95% CI, 21%-25%, from 14 articles), and for contractile strain of 17% (95% CI, 16%-19%, from 18 articles). Meta-regression identified heart rate (P = .02) and body surface area (P = .003) as contributors to this heterogeneity. Subgroup analyses revealed heterogeneity due to sample size (n > 100 vs N < 100, P = .02).
Conclusions: The normal reference ranges for the three components of left atrial function are demonstrated. The between-study heterogeneity is explained partly by heart rate, body surface area, and sample size.
Item Details
Item Type: | Refereed Article |
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Keywords: | strain, atrial, normal range, meta-analysis |
Research Division: | Biomedical and Clinical Sciences |
Research Group: | Cardiovascular medicine and haematology |
Research Field: | Cardiology (incl. cardiovascular diseases) |
Objective Division: | Health |
Objective Group: | Clinical health |
Objective Field: | Clinical health not elsewhere classified |
UTAS Author: | Pathan, F (Dr Faraz Pathan) |
UTAS Author: | D'Elia, N (Mr Nic D'Elia) |
UTAS Author: | Nolan, MT (Mr Mark Nolan) |
UTAS Author: | Marwick, TH (Professor Tom Marwick) |
UTAS Author: | Negishi, K (Dr Kazuaki Negishi) |
ID Code: | 114685 |
Year Published: | 2017 |
Web of Science® Times Cited: | 233 |
Deposited By: | Menzies Institute for Medical Research |
Deposited On: | 2017-02-23 |
Last Modified: | 2022-08-25 |
Downloads: | 0 |
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