eCite Digital Repository

Two Families with an Autosomal Dominant Inheritance Pattern for Papillary Carcinoma of the Thyroid

Citation

Burgess, JR and Duffield, A and Wilkinson, SJ and Ware, R and Greenaway, TM and Percival, J and Hoffman, L, Two Families with an Autosomal Dominant Inheritance Pattern for Papillary Carcinoma of the Thyroid, Journal of Clinical Endocrinology and Metabolism, 82, (2) pp. 345-348. ISSN 0021-972X (1997) [Refereed Article]

DOI: doi:10.1210/jc.82.2.345

Abstract

Background: Papillary carcinoma of the thyroid (PTC) is the most prevalent malignancy of the thyroid gland. Although the majority of lesions are sporadic tumors, an established relationship exists between familial adenomatous polyposis (FAP) and PTC. Moreover, some authors postulate the existence of familial PTC as a distinct entity. Evidence for this is limited, however, there being few well characterized descriptions of pedigrees with high prevalence of PTC. Aims: The objective of the present study was to examine an apparent heritable predisposition to PTC occurring in two Tasmanian families in which PTC occurs commonly. Methods: Pedigree charts were constructed for both families and the medical records of the members reviewed. Results: In Pedigree I, 7 of 25 members had PTC (6 of these had coexisting multinodular goiter (MNG), and 11 others had MNG. In Pedigree II, identical male twins and their daughters had PTC. Conclusions: In both families there is evidence of autosomal dominant inheritance of PTC. The association of PTC with MNG suggests a possible role for MNG in tumor pathogenesis in hereditary PTC. The majority of the patients were diagnosed with PTC before commencement of prospective screening, indicating clinically relevant disease in the families described.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Oncology and Carcinogenesis
Research Field:Oncology and Carcinogenesis not elsewhere classified
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Cancer and Related Disorders
Author:Burgess, JR (Professor John Burgess)
Author:Wilkinson, SJ (Dr Stephen Wilkinson)
ID Code:11448
Year Published:1997
Web of Science® Times Cited:72
Deposited By:Surgery
Deposited On:1997-08-01
Last Modified:2014-10-21
Downloads:0

Repository Staff Only: item control page