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Mitochondrial genetic diversity, selection and recombination in a canine transmissible cancer

Citation

Strakova, A and Ni Leathlobhair, M and Wang, G-D and Yin, T-T and Airikkala-Otter, I and Allen, JL and Allum, KM and Bansse-Issa, L and Bisson, JL and Castillo Domracheva, A and de Castro, KF and Corrigan, AM and Cran, HR and Crawford, JT and Cutter, SM and Delgadillo Keenan, L and Donelan, EM and Faramade, IA and Flores Reynoso, E and Fotopoulou, E and Fruean, SN and Gallardo-Arrieta, F and Glebova, O and Hafelin Manrique, RF and Henriques, JJGP and Ignatenko, N and Koenig, D and Lanza-Perea, M and Lobetti, R and Lopez Quintana, AM and Losfelt, T and Marino, G and Martincorena, I and Martinez Castaneda, S and Martinez-Lopez, MF and Meyer, M and Nakanwagi, B and De Nardi, AB and Neunzig, W and Nixon, SJ and Onsare, MM and Ortega-Pacheco, A and Peleteiro, MC and Pye, RJ and Reece, JF and Rojas Gutierrez, J and Sadia, H and Schmeling, SK and Shamanova, O and Ssuna, RK and Steenland-Smit, AE and Svitich, A and Thoya Ngoka, I and Vitalaru, BA and de Vos, AP and de Vos, JP and Walkinton, O and Wedge, DC and Wehrle-Martinez, AS and van der Wel, MG and Widdowson, SAE and Murchison, EP, Mitochondrial genetic diversity, selection and recombination in a canine transmissible cancer, eLife, 5 Article e14552. ISSN 2050-084X (2016) [Refereed Article]


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Copyright Statement

Copyright 2016 Strakova et al. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/

DOI: doi:10.7554/eLife.14552

Abstract

Canine transmissible venereal tumour (CTVT) is a clonally transmissible cancer that originated approximately 11,000 years ago and affects dogs worldwide. Despite the clonal origin of the CTVT nuclear genome, CTVT mitochondrial genomes (mtDNAs) have been acquired by periodic capture from transient hosts. We sequenced 449 complete mtDNAs from a global population of CTVTs, and show that mtDNA horizontal transfer has occurred at least five times, delineating five tumour clades whose distributions track two millennia of dog global migration. Negative selection has operated to prevent accumulation of deleterious mutations in captured mtDNA, and recombination has caused occasional mtDNA re-assortment. These findings implicate functional mtDNA as a driver of CTVT global metastatic spread, further highlighting the important role of mtDNA in cancer evolution.

Item Details

Item Type:Refereed Article
Keywords:Dog, cancer biology, canine transmissible venereal tumour, evolutionary biology, genomics, mitochondria, transmissible cancer
Research Division:Biological Sciences
Research Group:Zoology
Research Field:Animal Immunology
Objective Division:Expanding Knowledge
Objective Group:Expanding Knowledge
Objective Field:Expanding Knowledge in the Agricultural and Veterinary Sciences
Author:Pye, RJ (Dr Ruth Pye)
ID Code:114265
Year Published:2016
Web of Science® Times Cited:8
Deposited By:Menzies Institute for Medical Research
Deposited On:2017-02-09
Last Modified:2017-04-27
Downloads:9 View Download Statistics

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