114265 Journal Article.pdf (348.17 kB)
Mitochondrial genetic diversity, selection and recombination in a canine transmissible cancer
journal contribution
posted on 2023-05-19, 01:39 authored by Strakova, A, Ni Leathlobhair, M, Wang, G-D, Yin, T-T, Airikkala-Otter, I, Allen, JL, Allum, KM, Bansse-Issa, L, Bisson, JL, Castillo Domracheva, A, de Castro, KF, Corrigan, AM, Cran, HR, Crawford, JT, Cutter, SM, Delgadillo Keenan, L, Donelan, EM, Faramade, IA, Flores Reynoso, E, Fotopoulou, E, Fruean, SN, Gallardo-Arrieta, F, Glebova, O, Hafelin Manrique, RF, Henriques, JJGP, Ignatenko, N, Koenig, D, Lanza-Perea, M, Lobetti, R, Lopez Quintana, AM, Losfelt, T, Marino, G, Martincorena, I, Martinez Castaneda, S, Martinez-Lopez, MF, Meyer, M, Nakanwagi, B, De Nardi, AB, Neunzig, W, Nixon, SJ, Onsare, MM, Ortega-Pacheco, A, Peleteiro, MC, Ruth PyeRuth Pye, Reece, JF, Rojas Gutierrez, J, Sadia, H, Schmeling, SK, Shamanova, O, Ssuna, RK, Steenland-Smit, AE, Svitich, A, Thoya Ngoka, I, Vitalaru, BA, de Vos, AP, de Vos, JP, Walkinton, O, Wedge, DC, Wehrle-Martinez, AS, van der Wel, MG, Widdowson, SAE, Murchison, EPCanine transmissible venereal tumour (CTVT) is a clonally transmissible cancer that originated approximately 11,000 years ago and affects dogs worldwide. Despite the clonal origin of the CTVT nuclear genome, CTVT mitochondrial genomes (mtDNAs) have been acquired by periodic capture from transient hosts. We sequenced 449 complete mtDNAs from a global population of CTVTs, and show that mtDNA horizontal transfer has occurred at least five times, delineating five tumour clades whose distributions track two millennia of dog global migration. Negative selection has operated to prevent accumulation of deleterious mutations in captured mtDNA, and recombination has caused occasional mtDNA re-assortment. These findings implicate functional mtDNA as a driver of CTVT global metastatic spread, further highlighting the important role of mtDNA in cancer evolution.
History
Publication title
eLifeVolume
5Article number
e14552Number
e14552Pagination
1-25ISSN
2050-084XDepartment/School
Menzies Institute for Medical ResearchPublisher
eLife Sciences Publications Ltd.Place of publication
United KingdomRights statement
Copyright 2016 Strakova et al. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/Repository Status
- Open