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Combination treatment with leptin and pioglitazone in a mouse model of Alzheimer’s disease

Citation

Fernandez-Martos, CM and Atkinson, RAK and Chuah, MI and King, AE and Vickers, JC, Combination treatment with leptin and pioglitazone in a mouse model of Alzheimer's disease, Alzheimer's & Dementia: Translational Research & Clinical Interventions pp. 1-15. ISSN 2352-8737 (2016) [Refereed Article]


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Copyright 2016 The Authors. Licensed under Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) http://creativecommons.org/licenses/by-nc-nd/4.0/

DOI: doi:10.1016/j.trci.2016.11.002

Abstract

Introduction: Combination therapy approaches may be necessary to address the many facets of pathologic change in the brain in Alzheimer's disease (AD). The drugs leptin and pioglitazone have previously been shown individually to have neuroprotective and anti-inflammatory actions, respectively, in animal models.

Methods: We studied the impact of combined leptin and pioglitazone treatment in 6-month-old APP/PS1 (APPswe/PSEN1dE9) transgenic AD mouse model.

Results: We report that an acute 2-week treatment with combined leptin and pioglitazone resulted in a reduction of spatial memory deficits (Y maze) and brain β-amyloid levels (soluble β-amyloid and amyloid plaque burden) relative to vehicle-treated animals. Combination treatment was also associated with amelioration in plaque-associated neuritic pathology and synapse loss, and also a significantly reduced neocortical glial response.

Discussion: Combination therapy with leptin and pioglitazone ameliorates pathologic changes in APP/PS1 mice and may represent a potential treatment approach for AD.

Item Details

Item Type:Refereed Article
Keywords:Alzheimer's disease, combination therapy
Research Division:Medical and Health Sciences
Research Group:Neurosciences
Research Field:Cellular Nervous System
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Nervous System and Disorders
Author:Fernandez-Martos, CM (Dr Carmen Fernandez-Martos)
Author:Atkinson, RAK (Mrs Rachel Atkinson)
Author:Chuah, MI (Dr Inn Chuah)
Author:King, AE (Associate Professor Anna King)
Author:Vickers, JC (Professor James Vickers)
ID Code:114254
Year Published:2016
Deposited By:Wicking Dementia Research and Education Centre
Deposited On:2017-02-09
Last Modified:2017-03-07
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