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Alterations in neurofilaments and the transformation of the cytoskeleton in axons may provide insight into the aberrant neuronal changes of Alzheimer's disease

Citation

Vickers, JC and Kirkcaldie, MT and Phipps, A and King, AE, Alterations in neurofilaments and the transformation of the cytoskeleton in axons may provide insight into the aberrant neuronal changes of Alzheimer's disease, Brain Research Bulletin, 126, (Pt 3) pp. 324-333. ISSN 0361-9230 (2016) [Refereed Article]

Copyright Statement

Copyright 2016 Published by Elsevier Inc.

DOI: doi:10.1016/j.brainresbull.2016.07.012

Abstract

Neurofilaments are major protein constituents of the brain, but are particularly abundant in specific subpopulations of neurons and likely have a key role in the regulation of axonal calibre. Neurofilament proteins may also be involved in the transformation of the neuronal cytoskeleton leading to substantial tau pathology in axons damaged by Aβ, subsequently leading to neurofibrillary pathology in their cell bodies of origin. An understanding of neurofilamentous changes in axons and subsequent tau pathology may provide insight into how Aβ pathology may stimulate an aberrant plasticity-related response of damaged neurons, leading to the progressive and degenerative changes in the neuronal cytoskeleton that result in synapse loss and neuronal degeneration.

Item Details

Item Type:Refereed Article
Keywords:Alzheimer's disease, axons, neurofilament, dystrophic neurites, plaque, tau
Research Division:Medical and Health Sciences
Research Group:Neurosciences
Research Field:Cellular Nervous System
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Nervous System and Disorders
Author:Vickers, JC (Professor James Vickers)
Author:Kirkcaldie, MT (Dr Matthew Kirkcaldie)
Author:Phipps, A (Mr Andrew Phipps)
Author:King, AE (Associate Professor Anna King)
ID Code:114249
Year Published:2016
Deposited By:Wicking Dementia Research and Education Centre
Deposited On:2017-02-09
Last Modified:2017-11-06
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