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Alterations in neurofilaments and the transformation of the cytoskeleton in axons may provide insight into the aberrant neuronal changes of Alzheimer's disease
journal contribution
posted on 2023-05-19, 01:37 authored by James VickersJames Vickers, Matthew KirkcaldieMatthew Kirkcaldie, Andrew PhippsAndrew Phipps, Anna KingAnna KingNeurofilaments are major protein constituents of the brain, but are particularly abundant in specific subpopulations of neurons and likely have a key role in the regulation of axonal calibre. Neurofilament proteins may also be involved in the transformation of the neuronal cytoskeleton leading to substantial tau pathology in axons damaged by Aβ, subsequently leading to neurofibrillary pathology in their cell bodies of origin. An understanding of neurofilamentous changes in axons and subsequent tau pathology may provide insight into how Aβ pathology may stimulate an aberrant plasticity-related response of damaged neurons, leading to the progressive and degenerative changes in the neuronal cytoskeleton that result in synapse loss and neuronal degeneration.
History
Publication title
Brain Research BulletinVolume
126Issue
Pt 3Pagination
324-333ISSN
0361-9230Department/School
Wicking Dementia Research Education CentrePublisher
Pergamon-Elsevier Science LtdPlace of publication
United KingdomRights statement
Copyright 2016 Published by Elsevier Inc.Repository Status
- Restricted