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Midsagittal corpus callosum area and conversion to multiple sclerosis after clinically isolated syndrome: A multicentre Australian cohort study


Odenthal, C and Simpson Jr, S and Oughton, J and van der Mei, I and Rose, S and Fripp, J and Lucas, R and Taylor, B and Dear, K and Ponsonby, A-L and Coulthard, A, and the Ausimmune AusLong Investigator Groups, Midsagittal corpus callosum area and conversion to multiple sclerosis after clinically isolated syndrome: A multicentre Australian cohort study, Journal of Medical Imaging and Radiation Oncology, 61, (4) pp. 453-460. ISSN 1754-9477 (2017) [Refereed Article]

Copyright Statement

Copyright 2016 The Royal Australian and New Zealand College of Radiologists

DOI: doi:10.1111/1754-9485.12570


INTRODUCTION: Patients presenting with clinically isolated syndrome (CIS) may proceed to clinically definite multiple sclerosis (CDMS). Midsagittal corpus callosum area (CCA) is a surrogate marker for callosal atrophy, and can be obtained from a standard MRI study. This study explores the relationship between CCA measured at CIS presentation (baseline) and at 5 years post presentation, with conversion from CIS to CDMS. The association between CCA and markers of disability progression is explored.

METHODS: Corpus callosum area was measured on MRI scans at presentation and 5-year review following diagnosis of a first demyelinating event, or evidence of progressive MS, in 143 participants in the Ausimmune/AusLong Study. Relationships between CCA (at baseline and follow-up) and clinical outcomes were assessed.

RESULTS: Mean CCA at baseline study was 6.63 cm2 (SD 1.01). Patients who converted to MS by 5-year review (n = 100) had a significantly smaller mean CCA at follow-up (6.22 vs. 6.74, P = 0.007). Greater CCA reduction was associated with higher annualized relapse rate over follow-up.

CONCLUSION: Baseline CCA obtained from standard MRI protocols may be compared with subsequent MRI examinations as a surrogate for neurodegeneration and cerebral atrophy in patients with MS. This study demonstrates an association between CCA and disability in individuals presenting with CIS who convert to MS.

Item Details

Item Type:Refereed Article
Keywords:atrophy, clinically isolated syndrome, corpus callosum, magnetic resonance imaging, multiple sclerosis
Research Division:Biomedical and Clinical Sciences
Research Group:Neurosciences
Research Field:Central nervous system
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Simpson Jr, S (Dr Steve Simpson JR)
UTAS Author:van der Mei, I (Professor Ingrid van der Mei)
UTAS Author:Taylor, B (Professor Bruce Taylor)
ID Code:114128
Year Published:2017 (online first 2016)
Web of Science® Times Cited:6
Deposited By:Menzies Institute for Medical Research
Deposited On:2017-02-07
Last Modified:2017-12-05

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