Odenthal, C and Simpson Jr, S and Oughton, J and van der Mei, I and Rose, S and Fripp, J and Lucas, R and Taylor, B and Dear, K and Ponsonby, A-L and Coulthard, A, and the Ausimmune AusLong Investigator Groups, Midsagittal corpus callosum area and conversion to multiple sclerosis after clinically isolated syndrome: A multicentre Australian cohort study, Journal of Medical Imaging and Radiation Oncology, 61, (4) pp. 453-460. ISSN 1754-9477 (2017) [Refereed Article]
Copyright 2016 The Royal Australian and New Zealand College of Radiologists
METHODS: Corpus callosum area was measured on MRI scans at presentation and 5-year review following diagnosis of a first demyelinating event, or evidence of progressive MS, in 143 participants in the Ausimmune/AusLong Study. Relationships between CCA (at baseline and follow-up) and clinical outcomes were assessed.
RESULTS: Mean CCA at baseline study was 6.63 cm2 (SD 1.01). Patients who converted to MS by 5-year review (n = 100) had a significantly smaller mean CCA at follow-up (6.22 vs. 6.74, P = 0.007). Greater CCA reduction was associated with higher annualized relapse rate over follow-up.
CONCLUSION: Baseline CCA obtained from standard MRI protocols may be compared with subsequent MRI examinations as a surrogate for neurodegeneration and cerebral atrophy in patients with MS. This study demonstrates an association between CCA and disability in individuals presenting with CIS who convert to MS.
|Item Type:||Refereed Article|
|Keywords:||atrophy, clinically isolated syndrome, corpus callosum, magnetic resonance imaging, multiple sclerosis|
|Research Division:||Medical and Health Sciences|
|Research Field:||Central Nervous System|
|Objective Group:||Clinical Health (Organs, Diseases and Abnormal Conditions)|
|Objective Field:||Nervous System and Disorders|
|Author:||Simpson Jr, S (Dr Steve Simpson JR)|
|Author:||van der Mei, I (Associate Professor Ingrid van der Mei)|
|Author:||Taylor, B (Professor Bruce Taylor)|
|Year Published:||2017 (online first 2016)|
|Deposited By:||Menzies Institute for Medical Research|
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