de Graaff, B and Neil, A and Si, L and Yee, KC and Sanderson, K and Gurrin, L and Palmer, AJ, Cost-effectiveness of different population screening strategies for hereditary haemochromatosis in Australia, Applied Health Economics and Health Policy, 15, (4) pp. 521-534. ISSN 1175-5652 (2017) [Refereed Article]
Copyright 2016 Springer International Publishing Switzerland
Methods: A Markov model using probabilistic decision analysis was developed comparing four adult screening strategies: the status quo (cascade and incidental screening), genotyping with blood and buccal samples and transferrin saturation followed by genotyping (TfS). Target populations were males (30 years) and females (45 years) of northern European ancestry. Cost-effectiveness was estimated from the government perspective over a lifetime horizon.
Results: All strategies for males were cost-effective compared to the status quo. The incremental costs (standard deviation) associated with genotyping (blood) were AUD7 (56), TfS AUD15 (45) and genotyping (buccal) AUD63 (56), producing ICERs of AUD1673, 4103 and 15,233/quality-adjusted life-year (QALY) gained, respectively. For females, only the TfS strategy was cost-effective, producing an ICER of AUD10,195/QALY gained. Approximately 3% of C282Y homozygotes were estimated to be identified with the status quo approach, compared with 40% with the proposed screening strategies.
Conclusion: This model estimated that genotyping and TfS strategies are likely to be more cost-effective screening strategies than the status quo.
|Item Type:||Refereed Article|
|Keywords:||aaemochromatosis, screening, cost-effectiveness|
|Research Group:||Applied economics|
|Research Field:||Health economics|
|Objective Group:||Clinical health|
|Objective Field:||Diagnosis of human diseases and conditions|
|UTAS Author:||de Graaff, B (Dr Barbara de Graaff)|
|UTAS Author:||Neil, A (Associate Professor Amanda Neil)|
|UTAS Author:||Si, L (Mr Lei Si)|
|UTAS Author:||Yee, KC (Dr Kwang Yee)|
|UTAS Author:||Sanderson, K (Associate Professor Kristy Sanderson)|
|UTAS Author:||Palmer, AJ (Professor Andrew Palmer)|
|Year Published:||2017 (online first 2016)|
|Web of Science® Times Cited:||5|
|Deposited By:||Menzies Institute for Medical Research|
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