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Clinicopathologic Studies of Thymic Carcinoids in Multiple Endocrine Neoplasia Type 1


Teh, BT and McArdle, J and Chan, SP and Menon, J and Hartley, L and Pullan, P and Ho, J and Khir, A and Wilkinson, SJ and Larsson, C and Cameron, D and Shepherd, JJ, Clinicopathologic Studies of Thymic Carcinoids in Multiple Endocrine Neoplasia Type 1, Medicine, 76, (1) pp. 21-29. ISSN 0025-7974 (1997) [Refereed Article]

DOI: doi:10.1097/00005792-199701000-00002


Thymic carcinoid is part of the multiple endocrine neoplasia type 1 (MEN1) syndrome occurring predominantly in male patients who were heavy smokers, presenting most commonly in middle age. In contrast with metastatic midgut carcinoids, MEN1-related thymic carcinoid is not associated with carcinoid syndrome, nor is it associated with Cushing syndrome, in contrast with sporadic thymic carcinoids. Local invasion and metastasis are common. Prognosis is poor because of late detection, lack of effective treatment, and the aggressive nature of the tumor. All patients with thymic carcinoids should be investigated for MEN1, including thorough clinical evaluation and family studies. Anterior mediastinal lesions in MEN1 male patients should be considered thymic carcinoids until proven otherwise. All male MEN1 patients and asymptomatic gene carriers should be warned of the risk of thymic carcinoids and the possible link to smoking. Computed tomography (CT) of the chest is recommended on first screening for MEN1 in male patients more than 25 years of age, followed by yearly chest X-rays and chest CT every 3 years. Prophylactic thymectomy should be carried out during subtotal or total parathyroidectomy on MEN1 patients.

Item Details

Item Type:Refereed Article
Research Division:Biomedical and Clinical Sciences
Research Group:Clinical sciences
Research Field:Endocrinology
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Wilkinson, SJ (Dr Stephen Wilkinson)
UTAS Author:Shepherd, JJ (Professor Joseph Shepherd)
ID Code:11391
Year Published:1997
Web of Science® Times Cited:96
Deposited By:Surgery
Deposited On:1997-08-01
Last Modified:2011-08-12

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