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Temporal upregulation of host surface receptors provides a window of opportunity for bacterial adhesion and disease

Citation

Kc, R and Shukla, SD and Walters, EH and O'Toole, RF, Temporal upregulation of host surface receptors provides a window of opportunity for bacterial adhesion and disease, Microbiology, 163, (4) pp. 421-430. ISSN 0026-2617 (2017) [Refereed Article]


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Copyright Statement

Copyright 2017 the Authors. Published by the Microbiology Society.

DOI: doi:10.1099/mic.0.000434

Abstract

Host surface receptors provide bacteria with a foothold from which to attach, colonize and in some cases, invade tissue and elicit human disease. In this review, we discuss several key host receptors and cognate adhesins that function in bacterial pathogenesis. In particular, we examine the elevated expression of host surface receptors such as CEACAM-1, CEACAM-6, ICAM-1 and PAFR in response to specific stimuli. We explore how upregulated receptors, in turn, expose the host to a range of bacterial infections in the respiratory tract. It is apparent that exploitation of receptor induction for bacterial adherence is not unique to one body system, but is also observed in the central nervous, gastrointestinal, and urogenital systems. Prokaryotic pathogens which utilize this mechanism for their infectivity include Streptococcus pneumoniae, Haemophilus influenzae, Neisseria meningitidis, and Escherichia coli. A number of approaches have been used, in both in vitro and in vivo experimental models, to inhibit bacterial attachment to temporally-expressed host receptors. Some of these novel strategies may advance future targeted interventions for the prevention and treatment of bacterial disease.

Item Details

Item Type:Refereed Article
Keywords:Chronic disease, bacterial infection
Research Division:Medical and Health Sciences
Research Group:Medical Microbiology
Research Field:Medical Bacteriology
Objective Division:Manufacturing
Objective Group:Human Pharmaceutical Products
Objective Field:Human Pharmaceutical Treatments (e.g. Antibiotics)
Author:Kc, R (Mr Rajendra KC)
Author:Walters, EH (Professor Haydn Walters)
Author:O'Toole, RF (Dr Ronan O'Toole)
ID Code:113832
Year Published:2017
Web of Science® Times Cited:1
Deposited By:Medicine (Discipline)
Deposited On:2017-01-24
Last Modified:2017-12-12
Downloads:4 View Download Statistics

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