eCite Digital Repository

Temporal upregulation of host surface receptors provides a window of opportunity for bacterial adhesion and disease


KC, R and Shukla, SD and Walters, EH and O'Toole, RF, Temporal upregulation of host surface receptors provides a window of opportunity for bacterial adhesion and disease, Microbiology, 163, (4) pp. 421-430. ISSN 0026-2617 (2017) [Refereed Article]

PDF (Manuscript)

Copyright Statement

Copyright 2017 the Authors. Published by the Microbiology Society.

DOI: doi:10.1099/mic.0.000434


Host surface receptors provide bacteria with a foothold from which to attach, colonize and, in some cases, invade tissue and elicit human disease. In this review, we discuss several key host receptors and cognate adhesins that function in bacterial pathogenesis. In particular, we examine the elevated expression of host surface receptors such as CEACAM-1, CEACAM-6, ICAM-1 and PAFR in response to specific stimuli. We explore how upregulated receptors, in turn, expose the host to a range of bacterial infections in the respiratory tract. It is apparent that exploitation of receptor induction for bacterial adherence is not unique to one body system, but is also observed in the central nervous, gastrointestinal and urogenital systems. Prokaryotic pathogens which utilize this mechanism for their infectivity include Streptococcus pneumoniae, Haemophilus influenzae, Neisseria meningitidis and Escherichia coli. A number of approaches have been used, in both in vitro and in vivo experimental models, to inhibit bacterial attachment to temporally expressed host receptors. Some of these novel strategies may advance future targeted interventions for the prevention and treatment of bacterial disease.

Item Details

Item Type:Refereed Article
Keywords:chronic disease, bacterial infection, platelet-activating factor receptor, Streptococcus pneumoniae, non-typeable Haemophilus influenzae, airway epithelium
Research Division:Biomedical and Clinical Sciences
Research Group:Medical microbiology
Research Field:Medical bacteriology
Objective Division:Manufacturing
Objective Group:Human pharmaceutical products
Objective Field:Human pharmaceutical treatments
UTAS Author:KC, R (Dr Rajendra KC)
UTAS Author:Walters, EH (Professor Haydn Walters)
UTAS Author:O'Toole, RF (Dr Ronan O'Toole)
ID Code:113832
Year Published:2017
Web of Science® Times Cited:22
Deposited By:Medicine
Deposited On:2017-01-24
Last Modified:2018-08-27
Downloads:116 View Download Statistics

Repository Staff Only: item control page