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TRPV1 Channels in Immune Cells and Hematological Malignancies

Citation

Omari, SA and Adams, MJ and Geraghty, DP, TRPV1 Channels in Immune Cells and Hematological Malignancies, Advances in Pharmacology/Ion Channel Pharmacology, Elsevier/Academic Press, DP Geraghty, LD Rash (ed), Kansas City, pp. 173-198. ISBN 9780128104132 (2017) [Research Book Chapter]

Copyright Statement

Copyright 2017 Elsevier Inc.

DOI: doi:10.1016/bs.apha.2017.01.002

Abstract

Transient receptor potential vanilloid-1 (TRPV1) is a member of the TRP family of channels that are responsible for nociceptive, thermal, and mechanical sensations. Originally associated exclusively with sensory neurons, TRPV1 is now known to be present in almost all organs, including cells of the immune system, where TRPV1 has been shown to play a pivotal role in inflammation and immunity. Monocytes, macrophages, and dendritic cells express TRPV1, with both mouse and human studies suggesting that TRPV1 activation protects against endotoxin-induced inflammation. In contrast, TRPV1 (and other TRP channels) appears to be required for T-cell receptor activation by mitogens. Additionally, studies in cell lines derived from hematological and other malignancies suggest altered expression/function of TRPV1 might serve as a target for novel cytotoxic therapies.

Item Details

Item Type:Research Book Chapter
Keywords:transient receptor potential vanilloid-1, vanilloid, capsaicin, hematological malignancy, cell death
Research Division:Medical and Health Sciences
Research Group:Pharmacology and Pharmaceutical Sciences
Research Field:Clinical Pharmacology and Therapeutics
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Blood Disorders
Author:Omari, SA (Dr Sofia Omari)
Author:Geraghty, DP (Professor Dominic Geraghty)
ID Code:113785
Year Published:2017
Deposited By:Health Sciences
Deposited On:2017-01-20
Last Modified:2018-09-25
Downloads:0

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