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The biology and pathology of hypoxia-ischemia: an update

Citation

Clarkson, AN and Sutherland, BA and Appleton, I, The biology and pathology of hypoxia-ischemia: an update, Archivum immunologiae et therapiae experimentalis, 53, (3) pp. 213-225. ISSN 0004-069X (2005) [Refereed Article]

Copyright Statement

Copyright 2005 Institute of Immunology and Experimental Therapy Polish Academy of Sciences

Official URL: http://www.iitd.pan.wroc.pl/en/AITE/

Abstract

After an hypoxic-ischemic (HI) insult, a multi-faceted complex cascade of events occurs that ultimately causes cell death and neurological damage to the central nervous system. The various cascades include, amongst others: immunological changes, such as the activation of the complement system and the generation of antibodies; increased inflammation through the actions of pro-inflammatory cytokines and chemokines; the production of reactive oxygen species leading to oxidative stress; and diminished mitochondrial function leading to the activation of apoptotic pathways and subsequent alteration in the function of neurons within the contralateral hemisphere. This review addresses the immunological aspects following HI, the role of various cytokines (both pro-inflammatory and anti-inflammatory) and chemokines after the induction of HI. In addition, the role of free radicals in producing HI-induced neurodegeneration and the contribution that mitochondrial dysfunction has in neuronal apoptotic cell death will be discussed. This review also covers the changes that the previously assumed "internal control", the contralateral hemisphere, undergoes due to HI and describes the difficulties associated with therapy intended to prevent neuronal injury associated with HI.

Item Details

Item Type:Refereed Article
Keywords:angiogenesis, immunity, inflammation, mitochondria
Research Division:Medical and Health Sciences
Research Group:Neurosciences
Research Field:Central Nervous System
Objective Division:Expanding Knowledge
Objective Group:Expanding Knowledge
Objective Field:Expanding Knowledge in the Medical and Health Sciences
Author:Sutherland, BA (Dr Brad Sutherland)
ID Code:113614
Year Published:2005
Web of Science® Times Cited:43
Deposited By:Office of the School of Medicine
Deposited On:2017-01-09
Last Modified:2017-04-12
Downloads:0

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