eCite Digital Repository

Regulation of microvascular flow and metabolism: An overview

Citation

Keske, MA and Dwyer, RM and Russell, RD and Blackwood, SJ and Brown, Aascha and Hu, Donghua and Premilovac, D and Richards, SM and Rattigan, S, Regulation of microvascular flow and metabolism: An overview, Clinical and Experimental Pharmacology and Physiology, 44, (1) pp. 143-149. ISSN 0305-1870 (2017) [Refereed Article]

Copyright Statement

Copyright 2016 John Wiley & Sons Australia, Ltd

DOI: doi:10.1111/1440-1681.12688

Abstract

Skeletal muscle is an important site for insulin to regulate blood glucose levels. It is estimated that skeletal muscle is responsible for ~80% of insulin-mediated glucose disposal in the post-prandial period. The classical action of insulin to increase muscle glucose uptake involves insulin binding to insulin receptors on myocytes to stimulate glucose transporter 4 (GLUT 4) translocation to the cell surface membrane, enhancing glucose uptake. However, an additional role of insulin that is often under-appreciated is its action to increase muscle perfusion thereby improving insulin and glucose delivery to myocytes. Either of these responses (myocyte and/or vascular) may be impaired in insulin resistance, and both impairments are apparent in type 2 diabetes, resulting in diminished glucose disposal by muscle. The aim of this review is to report on the growing body of literature suggesting that insulin-mediated control of skeletal muscle perfusion is an important regulator of muscle glucose uptake and that impairment of microvascular insulin action has important physiological consequences early in the pathogenesis of insulin resistance. This work was discussed at the 2015 Australian Physiological Society Symposium "Physiological mechanisms controlling microvascular flow and muscle metabolism".

Item Details

Item Type:Refereed Article
Keywords:Microvascular blood flow, muscle metabolism
Research Division:Medical and Health Sciences
Research Group:Clinical Sciences
Research Field:Endocrinology
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Diabetes
Author:Keske, MA (Dr Michelle Keske)
Author:Dwyer, RM (Dr Renee Dwyer)
Author:Russell, RD (Dr Ryan Russell)
Author:Blackwood, SJ (Ms Sarah Blackwood)
Author:Brown, Aascha (Ms Aascha Brown)
Author:Hu, Donghua (Mr Donghua Hu)
Author:Premilovac, D (Dr Dino Premilovac)
Author:Richards, SM (Dr Stephen Richards)
Author:Rattigan, S (Professor Stephen Rattigan)
ID Code:113598
Year Published:2017
Deposited By:Medicine (Discipline)
Deposited On:2017-01-09
Last Modified:2017-02-28
Downloads:0

Repository Staff Only: item control page