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Neuroprotection for ischaemic stroke: Translation from the bench to the bedside


Sutherland, BA and Minnerup, J and Balami, JS and Arba, F and Buchan, AM and Kleinschnitz, C, Neuroprotection for ischaemic stroke: Translation from the bench to the bedside, International Journal of Stroke, 7, (5) pp. 407-418. ISSN 1747-4930 (2012) [Refereed Article]

Copyright Statement

Copyright 2012 The Authors

DOI: doi:10.1111/j.1747-4949.2012.00770.x


Neuroprotection seeks to restrict injury to the brain parenchyma following an ischaemic insult by preventing salvageable neurons from dying. The concept of neuroprotection has shown promise in experimental studies, but has failed to translate into clinical success. Many reasons exist for this including the heterogeneity of human stroke and the lack of methodological agreement between preclinical and clinical studies. Even with the proposed Stroke Therapy Academic Industry Roundtable criteria for preclinical development of neuroprotective agents for stroke, we have still seen limited success in the clinic, an example being NXY-059, which fulfilled nearly all the Stroke Therapy Academic Industry Roundtable criteria. There are currently a number of ongoing trials for neuroprotective strategies including hypothermia and albumin, but the outcome of these approaches remains to be seen. Combination therapies with thrombolysis also need to be fully investigated, as restoration of oxygen and glucose will always be the best therapy to protect against cell death from stroke. There are also a number of promising neuroprotectants in preclinical development including haematopoietic growth factors, and inhibitors of the nicotinamide adenine dinucleotide phosphate oxidases, a source of free radical production which is a key step in the pathophysiology of acute ischaemic stroke. For these neuroprotectants to succeed, essential quality standards need to be adhered to; however, these must remain realistic as the evidence that standardization of procedures improves translational success remains absent for stroke.

Item Details

Item Type:Refereed Article
Keywords:acute stroke therapy, ischaemic cascade, ischaemic stroke, STAIR, translation
Research Division:Biomedical and Clinical Sciences
Research Group:Neurosciences
Research Field:Central nervous system
Objective Division:Expanding Knowledge
Objective Group:Expanding knowledge
Objective Field:Expanding knowledge in the health sciences
UTAS Author:Sutherland, BA (Associate Professor Brad Sutherland)
ID Code:113588
Year Published:2012
Web of Science® Times Cited:170
Deposited By:Office of the School of Medicine
Deposited On:2017-01-09
Last Modified:2017-11-06

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