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Cerebral blood flow alteration in neuroprotection following cerebral ischaemia

Citation

Sutherland, BA and Papadakis, M and Chen, R-L and Buchan, AM, Cerebral blood flow alteration in neuroprotection following cerebral ischaemia, The Journal of physiology, 589, (17) pp. 4105-14. ISSN 0022-3751 (2011) [Refereed Article]

Copyright Statement

Copyright 2011 The Authors

DOI: doi:10.1113/jphysiol.2011.209601

Abstract

The best neuroprotectant for acute ischaemic stroke would always be the rapid return of oxygen and glucose to physiological levels. This is currently provided by thrombolysis which restores blood flow to the ischaemic region. The attempt to confer neuroprotection by targeting the brain parenchyma has shown promise in experimental stroke models, but has unequivocally failed to translate to the clinic. Neuroprotective therapy primarily targets the biochemical cascade that produces cell death following cerebral ischaemia. However, these agents may also alter signal transduction that controls cerebral blood flow, for example glutamate, which may affect the outcome after ischaemia. In these cases, neuroprotection may potentially be due to the improved access to oxygen and glucose rather than biochemical prevention of cell death. Improvement in cerebral blood flow is an important but often overlooked effect of neuroprotective therapy, analogous to the protective effects of drug-induced hypothermia. This short review will discuss cerebral blood flow alteration and protection of the brain in the context of ischaemic preconditioning, oxygen sensing and thrombolysis. Future neuroprotection studies in cerebral ischaemia require stringent monitoring of cerebral blood flow, plus other physiological parameters. This will increase the chances that any protection observed may be able to translate to human therapy.

Item Details

Item Type:Refereed Article
Keywords:cerebral blood flow, stroke, cerebral ischaemia, neuroprotection
Research Division:Medical and Health Sciences
Research Group:Neurosciences
Research Field:Central Nervous System
Objective Division:Expanding Knowledge
Objective Group:Expanding Knowledge
Objective Field:Expanding Knowledge in the Medical and Health Sciences
Author:Sutherland, BA (Dr Brad Sutherland)
ID Code:113563
Year Published:2011
Web of Science® Times Cited:26
Deposited By:Office of the School of Medicine
Deposited On:2017-01-06
Last Modified:2017-11-06
Downloads:0

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