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Cross-sectional and longitudinal associations between serum inflammatory cytokines and knee bone marrow lesions in patients with knee osteoarthritis

Citation

Zhu, Z and Otahal, P and Wang, B and Jin, X and Laslett, LL and Wluka, AE and Antony, B and Han, W and Wang, X and Winzenberg, TM and Cicuttini, F and Jones, G and Ding, C, Cross-sectional and longitudinal associations between serum inflammatory cytokines and knee bone marrow lesions in patients with knee osteoarthritis, Osteoarthritis and Cartilage, 25, (4) pp. 499-505. ISSN 1063-4584 (2017) [Refereed Article]

Copyright Statement

Copyright 2016 Osteoarthritis Research Society International

DOI: doi:10.1016/j.joca.2016.10.024

Abstract

OBJECTIVE: To describe cross-sectional and longitudinal associations between serum levels of interleukin (IL) - 6, IL-17A, IL-17F, IL-23 and knee bone marrow lesions (BMLs) in patients with knee osteoarthritis (OA).

DESIGN: Patients (n = 192) with symptomatic knee OA (mean 63 years, range 50-79, female 53%) were assessed at baseline and after 24 months. At each time point, serum IL-6, IL-17A, IL-17F and IL-23 were measured using Bio-Plex® Multiplex Immunoassays with Luminex xMAP technology. Knee BMLs were scored using the modified whole organ MRI score (WORMS) from T2 weighted fat-suppressed fast spin echo magnetic resonance imaging (MRI). Multivariable linear regression and log binominal regression were used to determine the associations between cytokines and BMLs.

RESULTS: Baseline IL-6 (quarters) were significantly associated with total knee BMLs (P < 0.01 for the trend) as well as associated with an increase in BML score (P = 0.05 for the trend), after adjustment for confounders. Baseline IL-17F and IL-23 (highest quarters vs others) was associated with an increase in BML score in females (P = 0.04 for IL-17F; P = 0.01 for IL-23), but not in males, in multivariable analyses. In contrast, IL-17A was not significantly associated with BMLs in either females or males.

CONCLUSION: IL-6 is associated with increased knee BMLs in both females and males with OA. Serum IL-17F and IL-23 predicted increased knee BML scores in females only, suggesting that inflammation is involved in BML pathogenesis in knee OA, especially in women.

Item Details

Item Type:Refereed Article
Keywords:Bone marrow lesions, Inflammatory cytokines, Osteoarthritis
Research Division:Medical and Health Sciences
Research Group:Clinical Sciences
Research Field:Rheumatology and Arthritis
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Skeletal System and Disorders (incl. Arthritis)
Author:Zhu, Z (Mr Zhao Zhu)
Author:Otahal, P (Mr Petr Otahal)
Author:Jin, X (Mr Xingzhong Jin)
Author:Laslett, LL (Dr Laura Laslett)
Author:Antony, B (Dr Benny Antony)
Author:Han, W (Dr Weiyu Han)
Author:Wang, X (Ms Xia Wang)
Author:Winzenberg, TM (Professor Tania Winzenberg)
Author:Jones, G (Professor Graeme Jones)
Author:Ding, C (Professor Chang-Hai Ding)
ID Code:113284
Year Published:2017 (online first 2016)
Deposited By:Menzies Institute for Medical Research
Deposited On:2016-12-20
Last Modified:2017-03-22
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