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Registered report: Melanoma genome sequencing reveals frequent PREX2 mutations
Citation
Chroscinski, D and Sampey, D and Hewitt, A, Registered report: Melanoma genome sequencing reveals frequent PREX2 mutations, E-life, 3 Article e04180. ISSN 2045-5267 (2014) [Refereed Article]
Abstract
The Reproducibility Project: Cancer Biology seeks to address growing concerns about reproducibility in scientific research by conducting replications of 50 papers in the field of cancer biology published between 2010 and 2012. This Registered Report describes the proposed replication plan of key experiments from "Melanoma genome sequencing reveals frequent PREX2 mutations" by Berger and colleagues, published in Nature in 2012 (Berger et al., 2012). The key experiments that will be replicated are those reported in Figure 3B and Supplementary Figure S6. In these experiments, Berger and colleagues show that somatic PREX2 mutations identified through whole-genome sequencing of human melanoma can contribute to enhanced lethality of tumor xenografts in nude mice (Figure 3B, S6B, and S6C; Berger et al., 2012). The Reproducibility Project: Cancer Biology is a collaboration between the Center for Open Science and Science Exchange, and the results of the replications will be published by eLife.
Item Details
Item Type: | Refereed Article |
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Keywords: | Reproducibility Project, Cancer Biology, cancer genomics, cell biology, driver mutations, human biology, medicine, melanoma, methodology, mouse |
Research Division: | Biomedical and Clinical Sciences |
Research Group: | Ophthalmology and optometry |
Research Field: | Ophthalmology |
Objective Division: | Health |
Objective Group: | Clinical health |
Objective Field: | Clinical health not elsewhere classified |
UTAS Author: | Hewitt, A (Professor Alex Hewitt) |
ID Code: | 113127 |
Year Published: | 2014 |
Web of Science® Times Cited: | 2 |
Deposited By: | Menzies Institute for Medical Research |
Deposited On: | 2016-12-14 |
Last Modified: | 2016-12-14 |
Downloads: | 0 |
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