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Erythrocyte polyunsaturated fatty acid status, memory, cognition and mood in older adults with mild cognitive impairment and healthy controls

Citation

Milte, CM and Sinn, N and Street, S and Buckley, JD and Coates, AM and Howe, PRC, Erythrocyte polyunsaturated fatty acid status, memory, cognition and mood in older adults with mild cognitive impairment and healthy controls, Prostaglandins, leukotrienes, and essential fatty acids, 84, (5-6) pp. 153-161. ISSN 0952-3278 (2011) [Refereed Article]

Copyright Statement

Copyright 2011 Elsevier Ltd.

DOI: doi:10.1016/j.plefa.2011.02.002

Abstract

Polyunsaturated fatty acid (PUFA) levels are altered in adults with cognitive decline and also depression. Depression facilitates progression from mild cognitive impairment (MCI) to dementia. We investigated associations between omega-3 (n-3) and omega-6 (n-6) PUFAs and cognition, memory and depression in 50 adults ≥65 years with MCI and 29 controls. Memory, depressive symptoms and erythrocyte PUFAs (% total fatty acids) were assessed. Eicosapentaenoic acid (EPA) was lower in MCI vs controls (.94% vs 1.26%, p<.01); n-6 PUFAs were higher: dihomo-gamma-linolenic acid (1.51% vs 1.32%, p<.01), arachidonic acid (11.54% vs 10.70%, p<.01), n-6 docosapentaenoic acid (DPA:.46% vs.34%, p<.01), and total n-6 PUFA (24.14% vs 23.37%, p<.05). Higher n-6 DPA predicted poorer mental health. Lower n-3 DPA was associated with higher self-reported bodily pain. Adults with MCI had higher depression scores (3.05.39 vs 1.33.24, p<.01). Depressive symptoms associated with elevated n-6 PUFA may contribute to cognitive decline in this population.

Item Details

Item Type:Refereed Article
Keywords:Mild cognitive impairment Dementia Depression Omega-3 fatty acids Omega-6 fatty acid
Research Division:Medical and Health Sciences
Research Group:Other Medical and Health Sciences
Research Field:Medical and Health Sciences not elsewhere classified
Objective Division:Health
Objective Group:Other Health
Objective Field:Health not elsewhere classified
Author:Street, S (Dr Steven Street)
ID Code:113038
Year Published:2011
Web of Science® Times Cited:23
Deposited By:Health Sciences
Deposited On:2016-12-08
Last Modified:2017-03-21
Downloads:0

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