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A monoclonal antibody to a human mast cell/myeloid leukaemia-specific antigen binds to normal haemopoietic progenitor cells and inhibits colony formation in vitro

Citation

Cambareri, AC and Ashman, LK and Cole, SR and Lyons, AB, A monoclonal antibody to a human mast cell/myeloid leukaemia-specific antigen binds to normal haemopoietic progenitor cells and inhibits colony formation in vitro, Leukemia Research, 12, (11-12) pp. 929-939. ISSN 0145-2126 (1988) [Refereed Article]

Copyright Statement

Copyright 1988 Pergamon-Elsevier Science Ltd.

DOI: doi:10.1016/0145-2126(88)90021-5

Abstract

An antigen identified by murine monoclonal antibody YB5.B8 has previously been detected only on acute non-lymphoblastic leukaemia (ANLL) cells and tissue mast cells. We now report that the YB5.B8 antigen is present on a minor population (up to 3%) of normal bone marrow mononuclear cells which overlaps the set of progenitor cells capable of forming haemopoietic colonies in vitro. The results indicate that the antigen is a normal haemopoietic progenitor cell marker which is selectively retained on mast cells during maturation, and that leukaemias which express the antigen are not necessarily committed to the mast cell lineage. Furthermore, the antibody was capable of partially inhibiting the formation of haemopoietic colonies in vitro, indicating an important functional role for the antigen. This is consistent with the observation, reported in the accompanying paper, that expression of the YB5.B8 antigen is strongly correlated with poor response to therapy in patients with ANLL.

Item Details

Item Type:Refereed Article
Keywords:Acute lymphocytic leukemia, chronic mylocytic leukemia, chromosome, haploidy, hyperploidy, oncogene, bcr
Research Division:Medical and Health Sciences
Research Group:Cardiorespiratory Medicine and Haematology
Research Field:Haematology
Objective Division:Health
Objective Group:Other Health
Objective Field:Health not elsewhere classified
Author:Lyons, AB (Dr Bruce Lyons)
ID Code:113014
Year Published:1988
Web of Science® Times Cited:27
Deposited By:Medicine (Discipline)
Deposited On:2016-12-07
Last Modified:2017-05-17
Downloads:0

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