Balogun, S and Winzenberg, T and Wills, K and Scott, D and Jones, G and Aitken, D and Callisaya, ML, Prospective associations of low muscle mass and function with 10-year falls risk, incident fracture and mortality in community-dwelling older adults, Journal of Nutrition, Health and Aging pp. 1-6. ISSN 1279-7707 (2016) [Refereed Article]
Copyright 2016 Serdi and Springer-Verlag France
Methods: 1041 participants (50% women; mean age 63±7.5 years) were prospectively followed for 10 years. Falls risk was measured using the Physiological Profile Assessment, fractures were self-reported and mortality was ascertained from the death registry. Appendicular lean mass (ALM) was assessed using dual energy X-ray absorptiometry. Four anthropometric: (ALM/height2, ALM/body mass index, ALM/weight×100, a residuals method of ALM on height and total body fat) and four performance-based measures: (handgrip strength, lower-limb muscle strength, upper and lower-limb muscle quality) were examined. Participants in the lowest 20% of the sex-specific distribution for each anthropometric and performance-based measure were classified has having low muscle mass or function. Regression analyses were used to estimate associations between each anthropometric and performance-based measure at baseline and 10-year falls risk, incident fractures and mortality.
Results: Mean falls risk z-score at 10 years was 0.64 (SD 1.12), incident fractures and mortality over 10 years were 16% and 14% respectively. All baseline performance based measures were significantly associated with higher falls risk score at 10 years. Low handgrip (RR 1.55, 95% CI: 1.09, 2.20) and ALM/body mass index (RR 1.54, 95% CI: 1.14, 2.08) were the only significant predictors of fracture and mortality respectively.
Conclusions: Low handgrip strength, a simple and inexpensive test could be considered in clinical settings for identifying future falls and fractures. ALM/ body mass index could be most suitable in estimating 10-year mortality risk, but requires specialised equipment.
|Item Type:||Refereed Article|
|Keywords:||Falls, fracture, mortality, muscle mass, muscle strength, sarcopenia|
|Research Division:||Medical and Health Sciences|
|Research Group:||Clinical Sciences|
|Research Field:||Rheumatology and Arthritis|
|Objective Group:||Clinical Health (Organs, Diseases and Abnormal Conditions)|
|Objective Field:||Skeletal System and Disorders (incl. Arthritis)|
|Author:||Balogun, S (Mr Saliu Balogun)|
|Author:||Winzenberg, T (Professor Tania Winzenberg)|
|Author:||Wills, K (Dr Karen Wills)|
|Author:||Jones, G (Professor Graeme Jones)|
|Author:||Aitken, D (Dr Dawn Aitken)|
|Author:||Callisaya, ML (Dr Michele Callisaya)|
|Deposited By:||Menzies Institute for Medical Research|
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