Silberstein, RB and Pipingas, A and Farrow, M and Levy, F and Stough, CK, Dopaminergic modulation of default mode network brain functional connectivity in attention deficit hyperactivity disorder, Brain and Behavior, 6, (12) Article e00582. ISSN 2162-3279 (2016) [Refereed Article]
Copyright 2016 The Authors. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/
Introduction: Recent evidence suggests that attention deficit hyperactivity disorder (ADHD) is associated with a range of brain functional connectivity abnormalities, with one of the most prominent being reduced inhibition of the default mode network (DMN) while performing a cognitive task. In this study, we examine the effects of a methylphenidate dose on brain functional connectivity in boys diagnosed with ADHD while they performed a cognitive task.
Method: Brain functional connectivity was estimated using steady-state visual evoked potential partial coherence before and 90 min after the administration of a methylphenidate dose to 42 stimulant drug-na´ve boys newly diagnosed with ADHD while they performed the A-X version of the continuous performance task (CPT A-X).
Results: Methylphenidate robustly reversed the transient functional connectivity increase in the A-X interval seen premedication to a postmedication decrease during this interval. In addition, methylphenidate-induced reductions in individual reaction time were correlated with corresponding reductions in functional connectivity.
Conclusion: These findings suggest that methylphenidate suppresses the increased functional connectivity observed in ADHD and that such suppression is associated with improved performance. Our findings support the suggestion that the increased functional connectivity we have observed in ADHD is associated with abnormal DMN activity. In addition, we comment on the significance of specific frequency channels mediating top-down communication within the cortex and the extent to which our findings are selectively sensitive to top-down intracortical communication.
|Item Type:||Refereed Article|
|Keywords:||brain functional connectivity, default mode network, dopamine, methylphenidate, steady-state visually evoked potential|
|Research Division:||Medical and Health Sciences|
|Research Field:||Neurosciences not elsewhere classified|
|Objective Group:||Clinical Health (Organs, Diseases and Abnormal Conditions)|
|Objective Field:||Nervous System and Disorders|
|Author:||Farrow, M (Dr Maree Farrow)|
|Web of Science® Times Cited:||3|
|Deposited By:||Wicking Dementia Research and Education Centre|
|Downloads:||8 View Download Statistics|
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