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Brain functional connectivity abnormalities in attention-deficit hyperactivity disorder


Silberstein, RB and Pipingas, A and Farrow, M and Levy, F and Stough, CK and Camfield, DA, Brain functional connectivity abnormalities in attention-deficit hyperactivity disorder, Brain and Behavior, 6, (12) Article e00583. ISSN 2162-3279 (2016) [Refereed Article]


Copyright Statement

Copyright 2016 The Authors. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0)

DOI: doi:10.1002/brb3.583


Introduction: Recent evidence suggests that attention-deficit hyperactivity disorder (ADHD) is associated with brain functional connectivity (FC) abnormalities.

Methods: In this study, we use steady-state visually evoked potential event-related partial coherence as a measure of brain FC to examine functional connectivity differences between a typically developing (TD) group of 25 boys and an age/IQ-matched group of 42 drug naive boys newly diagnosed with ADHD (ADHD group). Functional connectivity was estimated while both groups performed a low-demand reference task and the A-X version of the continuous performance task (CPT A-X).

Results: While the TD and ADHD groups exhibited similar prefrontal FC increases prior to the appearance of the target in the reference task, these groups demonstrated significant FC differences in the interval preceding the appearance of the target in the CPT A-X task. Specifically, the ADHD group exhibited robust prefrontal and parietofrontal FC increases that were not apparent in the TD group.

Conclusion: The FC differences observed in the ADHD group are discussed in the context of inaddequate suppression of cortical networks that may interfere with task performance.

Item Details

Item Type:Refereed Article
Keywords:brain functional connectivity, default mode network, steady state visually evoked potential
Research Division:Biomedical and Clinical Sciences
Research Group:Neurosciences
Research Field:Neurosciences not elsewhere classified
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Farrow, M (Dr Maree Farrow)
ID Code:112884
Year Published:2016
Web of Science® Times Cited:14
Deposited By:Wicking Dementia Research and Education Centre
Deposited On:2016-12-02
Last Modified:2017-10-31
Downloads:107 View Download Statistics

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