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Impact Acceleration Model of Diffuse Traumatic Brain Injury
chapter
posted on 2023-05-22, 17:26 authored by Hellewell, SC, Jenna ZiebellJenna Ziebell, Lifshitz, J, Morganti-Kossmann, MCThe impact acceleration (I/A) model of traumatic brain injury (TBI) was developed to reliably induce diffuse traumatic axonal injury in rats in the absence of skull fractures and parenchymal focal lesions. This model replicates a pathophysiology that is commonly observed in humans with diffuse axonal injury (DAI) caused by acceleration-deceleration forces. These are typical consequences of motor vehicle accidents and falls, which do not necessarily require a direct impact to the closed skull. In this chapter, we describe in detail the methodology and materials required to produce in the laboratory the rat model of I/A. We review how the model can be adapted to induce various brain injury severities, and provide recommendations to overcome some of the most frequent complications/issues encountered with this model.
History
Publication title
Methods in Molecular Biology, Volume 1462, Injury Models of the Central Nervous SystemEditors
F Kobeissy, CE Dixon, RL Hayes and S MondelloPagination
253-66ISBN
978-1-4939-3814-8Department/School
Wicking Dementia Research Education CentrePublisher
SpringerPlace of publication
United StatesExtent
40Rights statement
Copyright 2016 Springer Science+Business Media New YorkRepository Status
- Restricted