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Impact Acceleration Model of Diffuse Traumatic Brain Injury

Citation

Hellewell, SC and Ziebell, JM and Lifshitz, J and Morganti-Kossmann, MC, Impact Acceleration Model of Diffuse Traumatic Brain Injury, Methods in Molecular Biology, Volume 1462, Injury Models of the Central Nervous System, Springer Nature, F Kobeissy, CE Dixon, RL Hayes and S Mondello (ed), United States, pp. 253-66. ISBN 978-1-4939-3814-8 (2016) [Research Book Chapter]

Copyright Statement

Copyright 2016 Springer Science+Business Media New York

DOI: doi:10.1007/978-1-4939-3816-2_15

Abstract

The impact acceleration (I/A) model of traumatic brain injury (TBI) was developed to reliably induce diffuse traumatic axonal injury in rats in the absence of skull fractures and parenchymal focal lesions. This model replicates a pathophysiology that is commonly observed in humans with diffuse axonal injury (DAI) caused by acceleration-deceleration forces. These are typical consequences of motor vehicle accidents and falls, which do not necessarily require a direct impact to the closed skull. In this chapter, we describe in detail the methodology and materials required to produce in the laboratory the rat model of I/A. We review how the model can be adapted to induce various brain injury severities, and provide recommendations to overcome some of the most frequent complications/issues encountered with this model.

Item Details

Item Type:Research Book Chapter
Keywords:diffuse traumatic brain injury, neuronal pathology, rat model, traumatic axonal injury
Research Division:Medical and Health Sciences
Research Group:Neurosciences
Research Field:Neurosciences not elsewhere classified
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Nervous System and Disorders
Author:Ziebell, JM (Dr Jenna Ziebell)
ID Code:112876
Year Published:2016
Deposited By:Wicking Dementia Research and Education Centre
Deposited On:2016-12-01
Last Modified:2017-02-21
Downloads:0

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