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Identification of myopia-associated WNT7B polymorphisms provides insights into the mechanism underlying the development of myopia

Citation

Miyake, M and Yamashiro, K and Tabara, Y and Suda, K and Morooka, S and Nakanishi, H and Khor, CC and Chen, P and Qiao, F and Nakata, I and Akagi-Kurashige, Y and Gotoh, N and Tsujikawa, A and Meguro, A and Kusuhara, S and Polasek, O and Hayward, C and Wright, AF and Campbell, H and Richardson, AJ and Schache, M and Takeuchi, M and Mackey, DA and Hewitt, AW and Cuellar, G and Shi, Y and Huang, L and Yang, Z and Leung, KH and Kao, PY and Yap, MK and Yip, SP and Moriyama, M and Ohno-Matsui, K and Mizuki, N and MacGregor, S and Vitart, V and Aung, T and Saw, SM and Tai, ES and Wong, TY and Cheng, CY and Baird, PN and Yamada, R and Matsuda, F and Yoshimura, N, Nagahama Study Group, Identification of myopia-associated WNT7B polymorphisms provides insights into the mechanism underlying the development of myopia, Nature Communications, 6 Article 6689. ISSN 2041-1723 (2015) [Refereed Article]

Copyright Statement

Copyright 2015 Macmillan Publishers Limited

DOI: doi:10.1038/ncomms7689

Abstract

Myopia can cause severe visual impairment. Here, we report a two-stage genome-wide association study for three myopia-related traits in 9,804 Japanese individuals, which was extended with trans-ethnic replication in 2,674 Chinese and 2,690 Caucasian individuals. We identify WNT7B as a novel susceptibility gene for axial length (rs10453441, Pmeta=3.9 10(-13) and corneal curvature (Pmeta=2.9 10(-40) and confirm the previously reported association between GJD2 and myopia. WNT7B significantly associates with extreme myopia in a case-control study with 1,478 Asian patients and 4,689 controls (odds ratio (OR)meta=1.13, Pmeta=0.011). We also find in a mouse model of myopia downregulation of WNT7B expression in the cornea and upregulation in the retina, suggesting its possible role in the development of myopia.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Ophthalmology and Optometry
Research Field:Ophthalmology
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Hearing, Vision, Speech and Their Disorders
Author:Mackey, DA (Professor David Mackey)
Author:Hewitt, AW (Dr Alex Hewitt)
ID Code:112663
Year Published:2015
Web of Science® Times Cited:14
Deposited By:Menzies Institute for Medical Research
Deposited On:2016-11-23
Last Modified:2017-11-07
Downloads:0

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