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Interaction of homocysteine, glutathione and 8-hydroxy-2'-deoxyguanosine in metabolic syndrome progression


Butkowski, EG and Al-Aubaidy, HA and Jelinek, HF, Interaction of homocysteine, glutathione and 8-hydroxy-2'-deoxyguanosine in metabolic syndrome progression, Clinical Biochemistry, 50, (3) pp. 116-120. ISSN 0009-9120 (2017) [Refereed Article]

Copyright Statement

Crown Copyright 2016 Published by Elsevier Inc. on behalf of The Canadian Society of Clinical Chemists

DOI: doi:10.1016/j.clinbiochem.2016.10.006


Purpose: The role of homocysteine (Hcy) and associated oxidative stress processes in the metabolic syndrome (MetS) continuum has not been explored extensively. Changes in Hcy and associated oxidative stress in relation to the number of metabolic syndrome factors present are explored in this study.

Method: Participants (n = 266) attending a rural diabetes screening clinic had their medical history recorded as well as body mass index, Hcy, glucose, cholesterol, glutathione (GSH), and 8-hydroxy-2-deoxyguanosine (8-OHdG) measured.

Result: A significant elevation in Hcy (9.5μmol/L  2 vs. 10.6μmol/L  3, p = 0.03) and 8-OHdG (307pg/mL  516 vs. 1130pg/mL  1155, p = 0.0001) was observed between the noMetS and MetS groups. Hcy increased with the addition of MetS factors paralleled by 8-OHdG and GSH. A dramatic increase was seen in 8-OHdG, nearly doubling between 2 MetS and 3 MetS factors present (p = 0.0001).

Conclusion: Homocysteine may be a useful marker together with 8-OHdG in assessing the extent of metabolic syndrome in a rural population.

Item Details

Item Type:Refereed Article
Keywords:homocysteine, 8-OHdG, glutathione, metabolic syndrome, oxidative stress
Research Division:Biomedical and Clinical Sciences
Research Group:Medical biochemistry and metabolomics
Research Field:Medical biochemistry - carbohydrates
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Al-Aubaidy, HA (Dr Hayder Al-Aubaidy)
ID Code:112654
Year Published:2017
Web of Science® Times Cited:6
Deposited By:Medicine
Deposited On:2016-11-22
Last Modified:2018-08-27

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