eCite Digital Repository

The evolution of the molecular response to stress and its relevance to trauma and stressor-related disorders


Burges Watson, IP and Brune, M and Bradley, AJ, The evolution of the molecular response to stress and its relevance to trauma and stressor-related disorders, Neuroscience and Biobehavioral Reviews, 68 pp. 134-47. ISSN 0149-7634 (2016) [Refereed Article]

Copyright Statement

2016 Elsevier Ltd

DOI: doi:10.1016/j.neubiorev.2016.05.010


The experience of "stress", in its broadest meaning, is an inevitable part of life. All living creatures have evolved multiple mechanisms to deal with such threats and challenges and to avoid damage to the organism that may be incurred from these stress responses. Trauma and stressor-related disorders are psychiatric conditions that are caused specifically by the experience of stress, though depression, anxiety and some other disorders may also be unleashed by stress. Stress, however, is not a mandatory criterion of these diagnoses. This article focuses on the evolution of the neurochemicals involved in the response to stress and the systems in which they function. This includes the skin and gut, and the immune system.

Evidence suggests that responses to stress are evolutionarily highly conserved, have wider involvement than the hypothalamic pituitary adrenal stress axis alone, and that excessive stress responses can produce stressor-related disorders in both humans and animals.

Item Details

Item Type:Refereed Article
Keywords:immunology and stress physiology, molecular evolution, skin and gut responses to stress, stress and stressor-related disorders
Research Division:Medical and Health Sciences
Research Group:Public Health and Health Services
Research Field:Mental Health
Objective Division:Health
Objective Group:Public Health (excl. Specific Population Health)
Objective Field:Mental Health
Author:Burges Watson, IP (Dr Paddy Burges Watson)
ID Code:112636
Year Published:2016
Web of Science® Times Cited:3
Deposited By:Medicine (Discipline)
Deposited On:2016-11-21
Last Modified:2018-03-07

Repository Staff Only: item control page