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Life-course risk factor levels and coronary artery calcification. The Cardiovascular Risk in Young Finns Study


Hartiala, O and Kajander, S and Knuuti, J and Ukkonen, H and Saraste, A and Rinta-Kiikka, I and Kainulainen, S and Kahonen, M and Hutri-Kahonen, N and Laitinen, T and Lehtimaki, T and Viikari, JSA and Hartiala, J and Juonala, M and Raitakari, OT and Magnussen, CG, Life-course risk factor levels and coronary artery calcification. The Cardiovascular Risk in Young Finns Study, International Journal of Cardiology, 225 pp. 23-29. ISSN 0167-5273 (2016) [Refereed Article]

Copyright Statement

2016 Elsevier Ireland Ltd.

DOI: doi:10.1016/j.ijcard.2016.09.080


BACKGROUND: Risk factors measured in early life have been shown to predict coronary artery calcium (CAC) in adulthood. However, limited data exist on when risk factor profiles of those who develop CAC diverge from those who do not. We investigated the associations of coronary heart disease risk factor trajectories beginning in adolescence and CAC measured at middle-age.

METHODS: CAC was measured among 589 participants aged 39-45years in whom cardiovascular risk factors (serum lipids, blood pressure, body mass index, physical activity, smoking habits, and fruit, vegetable, fish, and butter intake) had been collected in 1980, 1983, 1986, 2001, and 2007 as part of the Cardiovascular Risk in Young Finns Study.

RESULTS: Mean levels of low-density lipoprotein cholesterol (LDL-C), total cholesterol, apolipoprotein B (Apo-B), and systolic blood pressure (SBP) levels across the 27-year period were significantly higher among those with CAC vs. those without. The difference between the groups was 0.25mmol/l (95% confidence interval, 95%CI, 0.079-0.41) for LDL-C, 0.26mmol/l (95%CI 0.080-0.44) for total cholesterol, 0.05mmol/l (95%CI 0.0085-0.091) for Apo-B and 1.92mmHg (95%CI 0.10-3.74) for SBP after adjustment for other risk factors. Those with CAC at age 39-45years had higher serum lipid levels already in adolescence or early adulthood compared with those without CAC, with these differences becoming more pronounced during the life-course.

CONCLUSIONS: Long-time risk factor exposure to higher LDL-C, total cholesterol and Apo-B levels already starting in adolescence and higher SBP levels in adulthood is associated with CAC at middle-age.

Item Details

Item Type:Refereed Article
Keywords:Atherosclerosis, Coronary artery calcium, Life-course analysis, Risk factors
Research Division:Health Sciences
Research Group:Epidemiology
Research Field:Epidemiology not elsewhere classified
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Magnussen, CG (Associate Professor Costan Magnussen)
ID Code:112612
Year Published:2016
Web of Science® Times Cited:13
Deposited By:Menzies Institute for Medical Research
Deposited On:2016-11-17
Last Modified:2017-11-07

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