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Associations between depression and anxiety symptoms and retinal vessel caliber in adolescents and young adults
Citation
Meier, MH and Gillespie, NA and Hansell, NK and Hewitt, AW and Hickie, IB and Lu, Y and MacGregor, S and Medland, SE and Sun, C and Wong, TY and Wright, M and Zhu, G and Martin, NG and Mackey, DA, Associations between depression and anxiety symptoms and retinal vessel caliber in adolescents and young adults, Psychosomatic Medicine, 76, (9) pp. 732-738. ISSN 0033-3174 (2014) [Refereed Article]
DOI: doi:10.1097/PSY.0000000000000117
Abstract
METHODS: Participants were 865 adolescents and young adults who participated in the Brisbane Longitudinal Twin Study and the Twin Eye Study in Tasmania. Participants completed an assessment of depression/anxiety symptoms (the Somatic and Psychological Health Report) when they were 16.5 years old (mean age), and they underwent retinal imaging, on average, 2.5 years later (range, 2 years before to 7 years after the depression/anxiety assessment). Retinal vessel caliber was assessed using computer software.
RESULTS: Depression and anxiety symptoms were associated with wider retinal arteriolar caliber in this sample of adolescents and young adults (β = 0.09, p = .016), even after adjusting for other cardiovascular risk factors (β = 0.08, p = .025). Multiple regression analyses revealed that affective symptoms of depression/anxiety were associated with retinal vessel caliber independently of somatic symptoms.
CONCLUSIONS: Depression and anxiety symptoms are associated with measurable signs in the retinal microvasculature in early life, suggesting that pathological microvascular mechanisms linking depression/anxiety and cardiovascular disease may be operative from a young age.
Item Details
Item Type: | Refereed Article |
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Keywords: | depression, anxiety, retinal vessel caliber, cardiovascular, adolescence, young adults |
Research Division: | Biomedical and Clinical Sciences |
Research Group: | Ophthalmology and optometry |
Research Field: | Ophthalmology |
Objective Division: | Health |
Objective Group: | Clinical health |
Objective Field: | Clinical health not elsewhere classified |
UTAS Author: | Hewitt, AW (Professor Alex Hewitt) |
UTAS Author: | Mackey, DA (Professor David Mackey) |
ID Code: | 112609 |
Year Published: | 2014 |
Web of Science® Times Cited: | 17 |
Deposited By: | Menzies Institute for Medical Research |
Deposited On: | 2016-11-17 |
Last Modified: | 2017-11-07 |
Downloads: | 0 |
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