Meier, MH and Gillespie, NA and Hansell, NK and Hewitt, AW and Hickie, IB and Lu, Y and MacGregor, S and Medland, SE and Sun, C and Wong, TY and Wright, M and Zhu, G and Martin, NG and Mackey, DA, Associations between depression and anxiety symptoms and retinal vessel caliber in adolescents and young adults, Psychosomatic Medicine, 76, (9) pp. 732-738. ISSN 0033-3174 (2014) [Refereed Article]
METHODS: Participants were 865 adolescents and young adults who participated in the Brisbane Longitudinal Twin Study and the Twin Eye Study in Tasmania. Participants completed an assessment of depression/anxiety symptoms (the Somatic and Psychological Health Report) when they were 16.5 years old (mean age), and they underwent retinal imaging, on average, 2.5 years later (range, 2 years before to 7 years after the depression/anxiety assessment). Retinal vessel caliber was assessed using computer software.
RESULTS: Depression and anxiety symptoms were associated with wider retinal arteriolar caliber in this sample of adolescents and young adults (β = 0.09, p = .016), even after adjusting for other cardiovascular risk factors (β = 0.08, p = .025). Multiple regression analyses revealed that affective symptoms of depression/anxiety were associated with retinal vessel caliber independently of somatic symptoms.
CONCLUSIONS: Depression and anxiety symptoms are associated with measurable signs in the retinal microvasculature in early life, suggesting that pathological microvascular mechanisms linking depression/anxiety and cardiovascular disease may be operative from a young age.
|Item Type:||Refereed Article|
|Keywords:||depression, anxiety, retinal vessel caliber, cardiovascular, adolescence, young adults|
|Research Division:||Biomedical and Clinical Sciences|
|Research Group:||Ophthalmology and optometry|
|Objective Group:||Clinical health|
|Objective Field:||Clinical health not elsewhere classified|
|UTAS Author:||Hewitt, AW (Professor Alex Hewitt)|
|UTAS Author:||Mackey, DA (Professor David Mackey)|
|Web of Science® Times Cited:||17|
|Deposited By:||Menzies Institute for Medical Research|
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