McAuley, AK and Dirani, M and Wang, JJ and Connell, PP and Lamoureux, EL and Hewitt, AW, A genetic variant regulating miR-126 is associated with sight threatening diabetic retinopathy, Diabetes and Vascular Disease Research, 12, (2) pp. 133-138. ISSN 1479-1641 (2015) [Refereed Article]
Copyright 2015 The Authors
MATERIALS AND METHODS: A case control study of 531 individuals with diabetes was genotyped for the rs4636297 SNP, using the Sequenom iPLEX Gold chemistry. STDR included people with severe non-proliferative diabetic retinopathy (NPDR) or proliferative diabetic retinopathy (PDR). Association was tested using logistic regression analysis, adjusting for confounding variables.
RESULTS: In an additive model, the A allele of rs4636297 SNP is significantly associated with STDR compared to people with none or mild diabetic retinopathy (DR) (odds ratio (OR) = 2.02, 95% confidence interval (CI) = 1.22-3.35, p = 0.006).
CONCLUSION: The A allele of rs4636297, known to be the non-functional allele for post-translational regulation of miR-126, is associated with STDR. This finding suggests that this locus would be a potential therapeutic target for inhibiting the development of DR.
|Item Type:||Refereed Article|
|Keywords:||Diabetic retinopathy, miR-126, microRNA, microvasculature, single nucleotide polymorphism|
|Research Division:||Biomedical and Clinical Sciences|
|Research Group:||Ophthalmology and optometry|
|Objective Group:||Clinical health|
|Objective Field:||Clinical health not elsewhere classified|
|UTAS Author:||Hewitt, AW (Professor Alex Hewitt)|
|Web of Science® Times Cited:||27|
|Deposited By:||Menzies Institute for Medical Research|
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