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A genetic variant regulating miR-126 is associated with sight threatening diabetic retinopathy


McAuley, AK and Dirani, M and Wang, JJ and Connell, PP and Lamoureux, EL and Hewitt, AW, A genetic variant regulating miR-126 is associated with sight threatening diabetic retinopathy, Diabetes and Vascular Disease Research, 12, (2) pp. 133-138. ISSN 1479-1641 (2015) [Refereed Article]

Copyright Statement

Copyright 2015 The Authors

DOI: doi:10.1177/1479164114560160


BACKGROUND: The regulation of miR-126 by rs4636297 single nucleotide polymorphism (SNP) has been implicated in the pathogenesis of neovascularisation by promoting vascular endothelial growth factor, suggesting it could be associated with sight threatening diabetic retinopathy (STDR), but has not been previously investigated or reported.

MATERIALS AND METHODS: A case control study of 531 individuals with diabetes was genotyped for the rs4636297 SNP, using the Sequenom iPLEX Gold chemistry. STDR included people with severe non-proliferative diabetic retinopathy (NPDR) or proliferative diabetic retinopathy (PDR). Association was tested using logistic regression analysis, adjusting for confounding variables.

RESULTS: In an additive model, the A allele of rs4636297 SNP is significantly associated with STDR compared to people with none or mild diabetic retinopathy (DR) (odds ratio (OR) = 2.02, 95% confidence interval (CI) = 1.22-3.35, p = 0.006).

CONCLUSION: The A allele of rs4636297, known to be the non-functional allele for post-translational regulation of miR-126, is associated with STDR. This finding suggests that this locus would be a potential therapeutic target for inhibiting the development of DR.

Item Details

Item Type:Refereed Article
Keywords:Diabetic retinopathy, miR-126, microRNA, microvasculature, single nucleotide polymorphism
Research Division:Biomedical and Clinical Sciences
Research Group:Ophthalmology and optometry
Research Field:Ophthalmology
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Hewitt, AW (Professor Alex Hewitt)
ID Code:112590
Year Published:2015
Web of Science® Times Cited:30
Deposited By:Menzies Institute for Medical Research
Deposited On:2016-11-17
Last Modified:2017-11-03

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