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A pathogenic role for the integrin CD103 in experimental allergic airways disease

Citation

Fear, VS and Lai, SP and Zosky, GR and Perks, KL and Gorman, S and Blank, F and von Garnier, C and Stumbles, PA and Strickland, DH, A pathogenic role for the integrin CD103 in experimental allergic airways disease, Physiological Reports, 4, (21) Article e13021. ISSN 2051-817X (2016) [Refereed Article]


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Copyright Statement

Copyright 2016 The Authors. Physiological Reports Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/

DOI: doi:10.14814/phy2.13021

Abstract

The integrin CD103 is the aE chain of integrin aEb7 that is important in the maintenance of intraepithelial lymphocytes and recruitment of T cells and dendritic cells (DC) to mucosal surfaces. The role of CD103 in intestinal immune homeostasis has been well described, however, its role in allergic airway inflammation is less well understood. In this study, we used an ovalbumin (OVA)-induced, CD103-knockout (KO) BALB/c mouse model of experimental allergic airways disease (EAAD) to investigate the role of CD103 in disease expression, CD4+ T-cell activation and DC activation and function in airways and lymph nodes. We found reduced airways hyper-responsiveness and eosinophil recruitment to airways after aerosol challenge of CD103 KO compared to wild-type (WT) mice, although CD103 KO mice showed enhanced serum OVA-specific IgE levels. Following aerosol challenge, total numbers of effector and regulatory CD4+ T-cell subsets were significantly increased in the airways of WT but not CD103 KO mice, as well as a lack of DC recruitment into the airways in the absence of CD103. While total airway DC numbers, and their in vivo allergen capture activity, were essentially normal in steady-state CD103 KO mice, migration of allergen-laden airway DC to draining lymph nodes was disrupted in the absence of CD103 at 24 h after aerosol challenge. These data support a role for CD103 in the pathogenesis of EAAD in BALB/c mice through local control of CD4+ T cell and DC subset recruitment to, and migration from, the airway mucosa during induction of allergic inflammation.

Item Details

Item Type:Refereed Article
Keywords:Allergy, asthma, CD103, CD4 T cell, dendritic cell
Research Division:Medical and Health Sciences
Research Group:Cardiorespiratory Medicine and Haematology
Research Field:Respiratory Diseases
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Respiratory System and Diseases (incl. Asthma)
UTAS Author:Zosky, GR (Professor Graeme Zosky)
ID Code:112569
Year Published:2016
Deposited By:Medicine
Deposited On:2016-11-16
Last Modified:2017-11-03
Downloads:137 View Download Statistics

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