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A pathogenic role for the integrin CD103 in experimental allergic airways disease
Citation
Fear, VS and Lai, SP and Zosky, GR and Perks, KL and Gorman, S and Blank, F and von Garnier, C and Stumbles, PA and Strickland, DH, A pathogenic role for the integrin CD103 in experimental allergic airways disease, Physiological Reports, 4, (21) Article e13021. ISSN 2051-817X (2016) [Refereed Article]
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Copyright Statement
Copyright 2016 The Authors. Physiological Reports Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/
Abstract
The integrin CD103 is the aE chain of integrin aEb7 that is important in the
maintenance of intraepithelial lymphocytes and recruitment of T cells and
dendritic cells (DC) to mucosal surfaces. The role of CD103 in intestinal
immune homeostasis has been well described, however, its role in allergic airway
inflammation is less well understood. In this study, we used an ovalbumin
(OVA)-induced, CD103-knockout (KO) BALB/c mouse model of
experimental allergic airways disease (EAAD) to investigate the role of CD103
in disease expression, CD4+ T-cell activation and DC activation and function
in airways and lymph nodes. We found reduced airways hyper-responsiveness
and eosinophil recruitment to airways after aerosol challenge of CD103 KO
compared to wild-type (WT) mice, although CD103 KO mice showed
enhanced serum OVA-specific IgE levels. Following aerosol challenge, total
numbers of effector and regulatory CD4+ T-cell subsets were significantly
increased in the airways of WT but not CD103 KO mice, as well as a lack of
DC recruitment into the airways in the absence of CD103. While total airway
DC numbers, and their in vivo allergen capture activity, were essentially normal
in steady-state CD103 KO mice, migration of allergen-laden airway DC
to draining lymph nodes was disrupted in the absence of CD103 at 24 h after
aerosol challenge. These data support a role for CD103 in the pathogenesis of
EAAD in BALB/c mice through local control of CD4+ T cell and DC subset
recruitment to, and migration from, the airway mucosa during induction of
allergic inflammation.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Keywords: | Allergy, asthma, CD103, CD4 T cell, dendritic cell |
| Research Division: | Biomedical and Clinical Sciences |
| Research Group: | Cardiovascular medicine and haematology |
| Research Field: | Respiratory diseases |
| Objective Division: | Health |
| Objective Group: | Clinical health |
| Objective Field: | Clinical health not elsewhere classified |
| UTAS Author: | Zosky, GR (Professor Graeme Zosky) |
| ID Code: | 112569 |
| Year Published: | 2016 |
| Deposited By: | Medicine |
| Deposited On: | 2016-11-16 |
| Last Modified: | 2017-11-03 |
| Downloads: | 169 View Download Statistics |
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