Han, W and Aitken, D and Zhu, Z and Halliday, A and Wang, X and Antony, B and Cicuttini, F and Jones, G and Ding, C, Hypointense signals in the infrapatellar fat pad assessed by magnetic resonance imaging are associated with knee symptoms and structure in older adults: a cohort study, Arthritis Research & Therapy, 18, (1) Article 234. ISSN 1478-6362 (2016) [Refereed Article]
Copyright 2016 The Authors. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/
METHODS: Participants (n = 874) were selected randomly from local community and followed up 2.7 years later (range 2.6-3.3 years). T1- or T2-weighted fat-suppressed magnetic resonance imaging (MRI) was assessed for IPFP hypointense signal, cartilage volume, cartilage defects, and bone marrow lesions (BMLs). Knee pain was assessed by self-administered Western Ontario and McMaster Osteoarthritis Index (WOMAC) questionnaire. Radiographic osteoarthritis was assessed using the OARSI atlas.
RESULTS: Cross-sectionally, hypointense signals in the IPFP were significantly associated with a higher risk of knee cartilage defects at all sites, tibiofemoral BMLs and knee pain in multivariable analyses. Longitudinally, baseline signal abnormalities were significantly and positively associated with increases in knee cartilage defects (OR: 2.27, 95 % CI: 1.61-3.21), BMLs (OR: 1.91, 95 % CI: 1.39-2.62), and knee pain (OR: 1.36, 95 % CI: 1.05-1.76) in multivariable analyses. The associations with cartilage defects remained significant after adjustment for BMLs, but the associations with BMLs and knee pain decreased in magnitude or became non-significant after further adjustment for cartilage defects.
CONCLUSIONS: Hypointense signals in the IPFP were associated primarily with increased knee cartilage defects and also with BMLs and knee symptoms in cross-sectional and longitudinal analyses, suggesting the abnormality represented by this signal has a potentially important role in osteoarthritis progression.
|Item Type:||Refereed Article|
|Keywords:||Infrapatellar fat pad, Osteoarthritis, Signal intensity, Cartilage defects, Bone marrow lesions, Pain|
|Research Division:||Biomedical and Clinical Sciences|
|Research Group:||Clinical sciences|
|Research Field:||Rheumatology and arthritis|
|Objective Group:||Clinical health|
|Objective Field:||Clinical health not elsewhere classified|
|UTAS Author:||Han, W (Dr Weiyu Han)|
|UTAS Author:||Aitken, D (Associate Professor Dawn Aitken)|
|UTAS Author:||Zhu, Z (Mr Zhaohua Zhu)|
|UTAS Author:||Wang, X (Ms Xia Wang)|
|UTAS Author:||Antony, B (Dr Benny Eathakkattu Antony)|
|UTAS Author:||Jones, G (Professor Graeme Jones)|
|UTAS Author:||Ding, C (Professor Chang-Hai Ding)|
|Web of Science® Times Cited:||21|
|Deposited By:||Menzies Institute for Medical Research|
|Downloads:||144 View Download Statistics|
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