Zhu, Z and Ding, C and Jin, X and Eathakkattu Antony, BS and Han, W and Laslett, LL and Cicuttini, F and Jones, G, Patellofemoral bone marrow lesions: natural history and associations with pain and structure, Arthritis Care & Research, 68, (11) pp. 1647-1654. ISSN 2151-464X (2016) [Refereed Article]
Copyright 2016 American College of Rheumatology
METHODS: A prospective population-based cohort study of men and women ages 50-80 years (mean age 63 years, n = 406) was performed. PF joint BMLs, knee cartilage volume, and cartilage defect scores (range 0-4) were measured using the Whole-Organ Magnetic Resonance Imaging Score system at baseline and at 2.6 years. Knee pain was assessed by Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scores at baseline and at 5 years.
RESULTS: At baseline, 27% (n = 109) had PF joint BMLs; 24% of these increased (WOMAC score change of ≥1) at followup, 44% persisted, 32% decreased, and 21% resolved completely. Of those without PF joint BMLs at baseline, 20% of participants developed PF joint BMLs over 2.6 years. In multivariable analyses, a change in PF joint BMLs was deleteriously associated with a change in total knee pain (β = 0.67, 95% confidence interval [95% CI] 0.03, 1.31) and knee pain when going up/down stairs (β = 0.24, 95% CI 0.04, 0.44) over 5 years. Baseline PF joint and tibiofemoral joint cartilage volume were protective for PF joint BMLs (relative risk [RR] 0.69, 95% CI 0.52, 0.90 for PF joint), while baseline PF joint cartilage defects were associated with an increase in PF joint BMLs (RR 1.73, 95% CI 1.38, 2.17) over 2.6 years. TF joint cartilage defects were not associated with increases in PF joint BMLs.
CONCLUSION: PF joint BMLs are not static, and change is clinically relevant. PF joint cartilage morphology predicts increases in PF joint BMLs.
|Item Type:||Refereed Article|
|Research Division:||Medical and Health Sciences|
|Research Group:||Clinical Sciences|
|Research Field:||Rheumatology and Arthritis|
|Objective Group:||Clinical Health (Organs, Diseases and Abnormal Conditions)|
|Objective Field:||Skeletal System and Disorders (incl. Arthritis)|
|Author:||Zhu, Z (Mr Zhao Zhu)|
|Author:||Ding, C (Professor Chang-Hai Ding)|
|Author:||Jin, X (Mr Xingzhong Jin)|
|Author:||Eathakkattu Antony, BS (Mr Benny Eathakkattu Antony)|
|Author:||Han, W (Dr Weiyu Han)|
|Author:||Laslett, LL (Dr Laura Laslett)|
|Author:||Jones, G (Professor Graeme Jones)|
|Web of Science® Times Cited:||2|
|Deposited By:||Menzies Institute for Medical Research|
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