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Echocardiographic screening for non-ischaemic stage B heart failure in the community
Citation
Yang, H and Negishi, K and Wang, Y and Nolan, M and Saito, M and Marwick, TH, Echocardiographic screening for non-ischaemic stage B heart failure in the community, European Journal of Heart Failure, 18, (11) pp. 1331-1339. ISSN 1388-9842 (2016) [Refereed Article]
Copyright Statement
© 2016 The Authors
DOI: doi:10.1002/ejhf.643
Abstract
METHODS AND RESULTS: Asymptomatic patients ≥65 years old, with ≥1 HF risk factor (hypertension, type 2 diabetes, or obesity) were recruited from the community; patients with valve disease, reduced ejection fraction (EF), and atrial fibrillation (AF) were excluded. Patients underwent standard clinical evaluation including calculation of the Charlson co-morbidity score and a comprehensive echocardiography including global longitudinal strain (GLS). Functional capacity was assessed by 6 min walk test. New HF and cardiovascular death were assessed after a mean follow-up of 14 ± 4 months by three independent cardiologists using Framingham criteria. Of 410 subjects (median age 70 years; 48% men), the prevalence of stage B HF was 13% [by LV hypertrophy (LVH)], 12% (by abnormal E/e'), 33% (by impaired GLS), and 31% [by left atrial enlargement (LAE)]. New HF symptoms developed in 49, and 2 died of cardiovascular causes, giving an event rate of 104/1000 person-years. These patients were older (P = 0.012), had a higher Charlson co-morbidity score (P < 0.001), larger LV mass and left atrium, higher E/e', and lower GLS (P < 0.05). LAE, LVH, abnormal GLS, and E/e' were independent predictors of new HF. In sequential models, LV mass and GLS added incremental information to clinical parameters. GLS significantly reclassified individuals (P = 0.002), but no reclassification improvement was identified using LV mass index, E/e', and left atrial volume index.
CONCLUSION: Echocardiographic assessment (especially GLS and LV mass) provides incremental value in predicting incident HF.
Item Details
Item Type: | Refereed Article |
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Keywords: | Community, Echocardiography, Global longitudinal strain, Heart failure, Screening |
Research Division: | Biomedical and Clinical Sciences |
Research Group: | Cardiovascular medicine and haematology |
Research Field: | Cardiology (incl. cardiovascular diseases) |
Objective Division: | Health |
Objective Group: | Clinical health |
Objective Field: | Clinical health not elsewhere classified |
UTAS Author: | Yang, H (Ms Hilda Yang) |
UTAS Author: | Negishi, K (Dr Kazuaki Negishi) |
UTAS Author: | Wang, Y (Ms Ying Wang) |
UTAS Author: | Nolan, M (Mr Mark Nolan) |
UTAS Author: | Saito, M (Dr Makoto Saito) |
UTAS Author: | Marwick, TH (Professor Tom Marwick) |
ID Code: | 112523 |
Year Published: | 2016 |
Web of Science® Times Cited: | 55 |
Deposited By: | Menzies Institute for Medical Research |
Deposited On: | 2016-11-15 |
Last Modified: | 2022-08-25 |
Downloads: | 0 |
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