eCite Digital Repository
Tryptophan metabolism, its relation to inflammation and stress markers and association with psychological and cognitive functioning: Tasmanian Chronic Kidney Disease pilot study
Citation
Karu, N and McKercher, C and Nichols, DS and Davies, N and Shellie, RA and Hilder, EF and Jose, MD, Tryptophan metabolism, its relation to inflammation and stress markers and association with psychological and cognitive functioning: Tasmanian Chronic Kidney Disease pilot study, BMC Nephrology, 17, (1) Article 171. ISSN 1471-2369 (2016) [Refereed Article]
![]() | PDF 487Kb |
Copyright Statement
© The Author(s) 2016 Licensed under Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/)
DOI: doi:10.1186/s12882-016-0387-3
Abstract
METHODS: Twenty-seven adults with CKD were part of 49 patients recruited to participate in a prospective pilot study, initially with an eGFR of 15-29 mL/min/1.73 m2. Only participants with viable blood samples and complete psychological/cognitive data at a 2-year follow-up were included in the reported cross-sectional study. Serum samples were analysed by Liquid Chromatography coupled to Mass Spectrometry, for tryptophan, ten of its metabolites, the inflammation marker neopterin and the hypothalamic-pituitary-adrenal (HPA) axis marker cortisol.
RESULTS: The tryptophan breakdown index (kynurenine / tryptophan) correlated with neopterin (Pearson R = 0.51 P = 0.006) but not with cortisol. Neopterin levels also correlated with indoxyl sulfate (R = 0.68, P < 0.0001) and 5 metabolites of tryptophan (R range 0.5-0.7, all P ≤ 0.01), which were all negatively related to eGFR (P < 0.05). Higher levels of kynurenic acid were associated with lower cognitive functioning (Spearman R = -0.39, P < 0.05), while indole-3 acetic acid (IAA) was correlated with anxiety and depression (R = 0.52 and P = 0.005, R = 0.39 and P < 0.05, respectively).
CONCLUSIONS: The results of this preliminary study suggest the involvement of inflammation in tryptophan breakdown via the kynurenine pathway, yet without sparing tryptophan metabolism through the 5-HT (serotonin) pathway in CKD patients. The multiple moderate associations between indole-3 acetic acid and psychological measures were a novel finding. The presented pilot data necessitate further exploration of these associations within a large prospective cohort to assess the broader significance of these findings.
Item Details
Item Type: | Refereed Article |
---|---|
Keywords: | Chronic kidney disease, Tryptophan, Kynurenine, Neopterin, Cortisol, Inflammation, Depression, Anxiety, Cognition |
Research Division: | Biomedical and Clinical Sciences |
Research Group: | Clinical sciences |
Research Field: | Nephrology and urology |
Objective Division: | Health |
Objective Group: | Public health (excl. specific population health) |
Objective Field: | Mental health |
UTAS Author: | Karu, N (Dr Naama Karu) |
UTAS Author: | McKercher, C (Dr Charlotte McKercher) |
UTAS Author: | Nichols, DS (Dr David Nichols) |
UTAS Author: | Davies, N (Associate Professor Noel Davies) |
UTAS Author: | Shellie, RA (Professor Robert Shellie) |
UTAS Author: | Hilder, EF (Professor Emily Hilder) |
UTAS Author: | Jose, MD (Professor Matthew Jose) |
ID Code: | 112506 |
Year Published: | 2016 |
Web of Science® Times Cited: | 52 |
Deposited By: | Menzies Institute for Medical Research |
Deposited On: | 2016-11-15 |
Last Modified: | 2022-08-30 |
Downloads: | 187 View Download Statistics |
Repository Staff Only: item control page