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Does upregulated host cell receptor expression provide a link between bacterial adhesion and chronic respiratory disease?
Citation
O'Toole, RF and Shukla, SD and Walters, EH, Does upregulated host cell receptor expression provide a link between bacterial adhesion and chronic respiratory disease?, Journal of Translational Medicine, 14 Article 304. ISSN 1479-5876 (2016) [Refereed Article]
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Copyright Statement
Copyright 2016 The Authors Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/
DOI: doi:10.1186/s12967-016-1063-x
Abstract
Expression of the platelet-activating factor receptor is upregulated in the respiratory epithelium of smokers and
chronic obstructive pulmonary disease patients. We have recently determined that increased expression of PAFr correlates
with higher levels of adhesion to human bronchial epithelial cells by non-typable Haemophilus influenzae and
Streptococcus pneumoniae which are major bacterial pathogens in acute exacerbations of COPD. In addition, we found
that a PAFr antagonist decreased the adhesion of both respiratory bacterial pathogens to non-cigarette exposure control
levels. This highlights the possibility that epithelial receptors, that are upregulated in response to cigarette smoke,
could be targeted to specifically block chronic bacterial infections of the lower respiratory tract. In this commentary,
we explore the question of whether adhesion to a temporally-upregulated host receptor is a common event in
chronic bacterial disease, and as such, could represent a putative therapeutic target for blocking infection by respiratory
and other pathogens
Item Details
| Item Type: | Refereed Article |
|---|---|
| Keywords: | COPD, airway epithelium, platelet-activating factor receptor, non-typeable haemophilus influenzae, Streptococcus pneumoniae |
| Research Division: | Medical and Health Sciences |
| Research Group: | Medical Microbiology |
| Research Field: | Medical Bacteriology |
| Objective Division: | Manufacturing |
| Objective Group: | Human Pharmaceutical Products |
| Objective Field: | Human Pharmaceutical Treatments (e.g. Antibiotics) |
| Author: | O'Toole, RF (Dr Ronan O'Toole) |
| Author: | Shukla, SD (Mr Shakti Shukla) |
| Author: | Walters, EH (Professor Haydn Walters) |
| ID Code: | 112109 |
| Year Published: | 2016 |
| Web of Science® Times Cited: | 2 |
| Deposited By: | Medicine (Discipline) |
| Deposited On: | 2016-10-27 |
| Last Modified: | 2017-12-14 |
| Downloads: | 45 View Download Statistics |
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