Colorectal cancer (CRC) is one of the most life threatening disease with escalating mortality and morbidity. Some known causative factors include lifestyle, alcohol etc. but there are other aspects like long standing colitis, inhibition of apoptotic proteins, chemokines and their receptors and inflammasomes which increase the chances of CRC progression. In a clinical setting of diseases like colitis and Crohn’s disease, the risk of CRC varies on degree of inflammation, expression of chemokines and cytokines and other molecular alterations. Hence, the underlying molecular inductions determine the fate of CRC progression through extent of epithelialmesenchymal transition, metastasis and invasive ability. The present view point will showcase some of the latent and notable considerations in CRC progression.

Item Type:	Contribution to Refereed Journal
Keywords:	colorectal cancer, hypoxia, proliferation
Research Division:	Biological Sciences
Research Group:	Biochemistry and Cell Biology
Research Field:	Cell Development, Proliferation and Death
Objective Division:	Health
Objective Group:	Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:	Digestive System Disorders
UTAS Author:	Gundamaraju, R (Mr Rohit Gundamaraju)
UTAS Author:	Vemuri, R (Mr Ravichandra Vemuri)
UTAS Author:	Eri, R (Associate Professor Raj Eri)
ID Code:	111942
Year Published:	2016
Deposited By:	Health Sciences
Deposited On:	2016-10-17
Last Modified:	2016-10-17
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