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Targeting mitochondrial function to treat optic neuropathy

Citation

Gueven, N and Nadikudi, M and Daniel, A and Chhetri, J, Targeting mitochondrial function to treat optic neuropathy, Mitochondrion, 36 pp. 7-14. ISSN 1567-7249 (2017) [Refereed Article]

Copyright Statement

2016 Published by Elsevier Ltd

DOI: doi:10.1016/j.mito.2016.07.013

Abstract

Many reports have illustrated a tight connection between vision and mitochondrial function. Not only are most mitochondrial diseases associated with some form of vision impairment, many ophthalmological disorders such as glaucoma, age-related macular degeneration and diabetic retinopathy also show signs of mitochondrial dysfunction. Despite a vast amount of evidence, vision loss is still only treated symptomatically, which is only partially a consequence of resistance to acknowledge that mitochondria could be the common denominator and hence a promising therapeutic target. More importantly, clinical support of this concept is only emerging. Moreover, only a few drug candidates and treatment strategies are in development or approved that selectively aim to restore mitochondrial function. This review rationalizes the currently developed therapeutic approaches that target mitochondrial function by discussing their proposed mode(s) of action and provides an overview on their development status with regards to optic neuropathies.

Item Details

Item Type:Refereed Article
Keywords:mitochondria, retinopathy, optic neuropathy, age-related macular degeneration, diabetic retinopathy, glaucoma, Leber's hereditary optic neuropathy, (LHON), mitochondrial dysfunction, CoQ10, idebenone, EPI-743, MitoQ SkQ1, ocluvia, MTP-131
Research Division:Medical and Health Sciences
Research Group:Ophthalmology and Optometry
Research Field:Ophthalmology
Objective Division:Expanding Knowledge
Objective Group:Expanding Knowledge
Objective Field:Expanding Knowledge in the Medical and Health Sciences
Author:Gueven, N (Dr Nuri Guven)
Author:Nadikudi, M (Ms Monila Nadikudi)
Author:Daniel, A (Mr Abraham Daniel)
Author:Chhetri, J (Ms Jamuna Chhetri)
ID Code:111888
Year Published:2017 (online first 2016)
Deposited By:Pharmacy
Deposited On:2016-10-13
Last Modified:2017-11-23
Downloads:0

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