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Targeting mitochondrial function to treat optic neuropathy
Citation
Gueven, N and Nadikudi, M and Daniel, AO and Chhetri, J, Targeting mitochondrial function to treat optic neuropathy, Mitochondrion, 36 pp. 7-14. ISSN 1567-7249 (2017) [Refereed Article]
Copyright Statement
© 2016 Published by Elsevier Ltd
DOI: doi:10.1016/j.mito.2016.07.013
Abstract
Many reports have illustrated a tight connection between vision and mitochondrial function. Not only are most mitochondrial diseases associated with some form of vision impairment, many ophthalmological disorders such as glaucoma, age-related macular degeneration and diabetic retinopathy also show signs of mitochondrial dysfunction. Despite a vast amount of evidence, vision loss is still only treated symptomatically, which is only partially a consequence of resistance to acknowledge that mitochondria could be the common denominator and hence a promising therapeutic target. More importantly, clinical support of this concept is only emerging. Moreover, only a few drug candidates and treatment strategies are in development or approved that selectively aim to restore mitochondrial function. This review rationalizes the currently developed therapeutic approaches that target mitochondrial function by discussing their proposed mode(s) of action and provides an overview on their development status with regards to optic neuropathies.
Item Details
Item Type: | Refereed Article |
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Keywords: | mitochondria, retinopathy, optic neuropathy, age-related macular degeneration, diabetic retinopathy, glaucoma, Leber's hereditary optic neuropathy, (LHON), mitochondrial dysfunction, CoQ10, idebenone, EPI-743, MitoQ SkQ1, ocluvia, MTP-131 |
Research Division: | Biomedical and Clinical Sciences |
Research Group: | Ophthalmology and optometry |
Research Field: | Ophthalmology |
Objective Division: | Expanding Knowledge |
Objective Group: | Expanding knowledge |
Objective Field: | Expanding knowledge in the health sciences |
UTAS Author: | Gueven, N (Dr Nuri Guven) |
UTAS Author: | Nadikudi, M (Ms Monila Nadikudi) |
UTAS Author: | Daniel, AO (Mr Abraham Daniel) |
UTAS Author: | Chhetri, J (Ms Jamuna Chhetri) |
ID Code: | 111888 |
Year Published: | 2017 (online first 2016) |
Web of Science® Times Cited: | 19 |
Deposited By: | Pharmacy |
Deposited On: | 2016-10-13 |
Last Modified: | 2017-11-23 |
Downloads: | 0 |
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