Zhu, Z and Jin, X and Wang, B and Wluka, A and Antony, B and Laslett, LL and Winzenberg, T and Cicuttini, F and Jones, G and Ding, C, Cross-sectional and longitudinal associations between serum levels of high-sensitivity C-reactive protein, knee bone marrow lesions, and knee pain in patients with knee osteoarthritis, Arthritis Care & Research, 68, (10) pp. 1471-1477. ISSN 2151-464X (2016) [Refereed Article]
Copyright 2016 American College of Rheumatology
METHODS: Patients (n = 192) with symptomatic knee OA (mean age 63 years, range 50-79, women 53%) were assessed at baseline and after 24 months. Serum hsCRP was measured using enzyme-linked immunosorbent assay. Knee BMLs were scored using the modified Whole-Organ Magnetic Resonance Imaging (MRI) Score from T2-weighted fat-supressed fast spin-echo MRI. Knee pain was assessed using the Western Ontario and McMaster Universities Osteoarthritis Index.
RESULTS: Quartiles of baseline serum hsCRP were associated with the presence of knee BMLs (prevalence ratio 1.07 per quartile [95% confidence interval (95% CI) 1.00, 1.15]) and total knee pain scores (β 13.66 per quartile [95% CI 2.26, 25.07]) in multivariable analyses. Longitudinally, higher baseline hsCRP was associated with an increase in BML score (risk ratio 1.37 per quartile [95% CI 1.10, 1.70]), and change in hsCRP was positively associated with change in BML score (β 0.19 [95% CI 0.05, 0.34]) in adjusted analyses. Baseline hsCRP was not associated with change in total knee pain, but change in hsCRP was positively and significantly associated with change in total knee pain (β 4.71 [95% CI 0.48, 8.94]). This became nonsignificant after adjustment for changes in BML score.
CONCLUSION: In patients with knee OA, serum hsCRP is associated with knee BML scores and, to a lesser extent, pain both cross-sectionally and longitudinally, suggesting that inflammation is linked with BMLs and their associated pain.
|Item Type:||Refereed Article|
|Research Division:||Medical and Health Sciences|
|Research Group:||Clinical Sciences|
|Research Field:||Rheumatology and Arthritis|
|Objective Group:||Clinical Health (Organs, Diseases and Abnormal Conditions)|
|Objective Field:||Skeletal System and Disorders (incl. Arthritis)|
|Author:||Zhu, Z (Mr Zhao Zhu)|
|Author:||Jin, X (Mr Xingzhong Jin)|
|Author:||Antony, B (Mr Benny Eathakkattu Antony)|
|Author:||Laslett, LL (Dr Laura Laslett)|
|Author:||Winzenberg, T (Professor Tania Winzenberg)|
|Author:||Jones, G (Professor Graeme Jones)|
|Author:||Ding, C (Professor Chang-Hai Ding)|
|Web of Science® Times Cited:||3|
|Deposited By:||Menzies Institute for Medical Research|
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