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Cross-sectional and longitudinal associations between serum levels of high-sensitivity C-reactive protein, knee bone marrow lesions, and knee pain in patients with knee osteoarthritis
Citation
Zhu, Z and Jin, X and Wang, B and Wluka, A and Antony, B and Laslett, LL and Winzenberg, T and Cicuttini, F and Jones, G and Ding, C, Cross-sectional and longitudinal associations between serum levels of high-sensitivity C-reactive protein, knee bone marrow lesions, and knee pain in patients with knee osteoarthritis, Arthritis Care & Research, 68, (10) pp. 1471-1477. ISSN 2151-464X (2016) [Refereed Article]
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Copyright Statement
Copyright 2016 American College of Rheumatology
Abstract
METHODS: Patients (n = 192) with symptomatic knee OA (mean age 63 years, range 50-79, women 53%) were assessed at baseline and after 24 months. Serum hsCRP was measured using enzyme-linked immunosorbent assay. Knee BMLs were scored using the modified Whole-Organ Magnetic Resonance Imaging (MRI) Score from T2-weighted fat-supressed fast spin-echo MRI. Knee pain was assessed using the Western Ontario and McMaster Universities Osteoarthritis Index.
RESULTS: Quartiles of baseline serum hsCRP were associated with the presence of knee BMLs (prevalence ratio 1.07 per quartile [95% confidence interval (95% CI) 1.00, 1.15]) and total knee pain scores (β 13.66 per quartile [95% CI 2.26, 25.07]) in multivariable analyses. Longitudinally, higher baseline hsCRP was associated with an increase in BML score (risk ratio 1.37 per quartile [95% CI 1.10, 1.70]), and change in hsCRP was positively associated with change in BML score (β 0.19 [95% CI 0.05, 0.34]) in adjusted analyses. Baseline hsCRP was not associated with change in total knee pain, but change in hsCRP was positively and significantly associated with change in total knee pain (β 4.71 [95% CI 0.48, 8.94]). This became nonsignificant after adjustment for changes in BML score.
CONCLUSION: In patients with knee OA, serum hsCRP is associated with knee BML scores and, to a lesser extent, pain both cross-sectionally and longitudinally, suggesting that inflammation is linked with BMLs and their associated pain.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Research Division: | Biomedical and Clinical Sciences |
| Research Group: | Clinical sciences |
| Research Field: | Rheumatology and arthritis |
| Objective Division: | Health |
| Objective Group: | Clinical health |
| Objective Field: | Clinical health not elsewhere classified |
| UTAS Author: | Zhu, Z (Mr Zhaohua Zhu) |
| UTAS Author: | Jin, X (Mr Xingzhong Jin) |
| UTAS Author: | Antony, B (Dr Benny Eathakkattu Antony) |
| UTAS Author: | Laslett, LL (Dr Laura Laslett) |
| UTAS Author: | Winzenberg, T (Professor Tania Winzenberg) |
| UTAS Author: | Jones, G (Professor Graeme Jones) |
| UTAS Author: | Ding, C (Professor Chang-Hai Ding) |
| ID Code: | 111667 |
| Year Published: | 2016 |
| Web of Science® Times Cited: | 13 |
| Deposited By: | Menzies Institute for Medical Research |
| Deposited On: | 2016-09-28 |
| Last Modified: | 2018-03-05 |
| Downloads: | 99 View Download Statistics |
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