Saul, A and Ponsonby, A-L and Lucas, RM and Taylor, BV and Simpson Jr, S and Valery, P and Dwyer, T and Kilpatrick, TJ and Pender, MP and van der Mei, IAF, Stressful life events and the risk of initial central nervous system demyelination, Multiple Sclerosis Journal, 23, (7) pp. 1000-1007. ISSN 1352-4585 (2017) [Refereed Article]
Copyright 2016 The Author(s)
OBJECTIVE: To examine the association between stressful life events and risk of first demyelinating event (FDE).
METHODS: This was a multicentre incident case-control study. Cases (n = 282 with first diagnosis of central nervous system (CNS) demyelination, including n = 216 with 'classic FDE') were aged 18-59 years. Controls without CNS demyelination (n = 558) were matched to cases on age, sex and study region. Stressful life events were assessed using a questionnaire based on the Social Readjustment Rating Scale.
RESULTS: Those who suffered from a serious illness in the previous 12 months were more likely to have an FDE (odds ratio (OR) = 2.35 (1.36, 4.06), p = 0.002), and when we limited our reference group to those who had no stressful life events, the magnitude of effect became stronger (OR = 5.41 (1.80, 16.28)). The total stress number and stress load were not convincingly associated with the risk of an FDE.
CONCLUSION: Cases were more likely to report a serious illness in the previous 12 months, which could suggest that a non-specific illness provides an additional strain to an already predisposed immune system.
|Item Type:||Refereed Article|
|Keywords:||First demyelinating event, first clinical diagnosis, multiple sclerosis, risk factors, stress, stressful life events|
|Research Division:||Medical and Health Sciences|
|Research Field:||Central Nervous System|
|Objective Group:||Clinical Health (Organs, Diseases and Abnormal Conditions)|
|Objective Field:||Nervous System and Disorders|
|Author:||Saul, A (Ms Alice Saul)|
|Author:||Taylor, BV (Professor Bruce Taylor)|
|Author:||Simpson Jr, S (Dr Steve Simpson JR)|
|Author:||van der Mei, IAF (Associate Professor Ingrid van der Mei)|
|Year Published:||2017 (online first 2016)|
|Deposited By:||Menzies Institute for Medical Research|
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