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Trace metal exposure is associated with increased exhaled nitric oxide in asthmatic children

Citation

Godri Pollitt, KJ and Maikawa, CL and Wheeler, AJ and Weichenthal, S and Dobbin, NA and Liu, L and Goldberg, MS, Trace metal exposure is associated with increased exhaled nitric oxide in asthmatic children, Environmental Health, 15, (1) Article 94. ISSN 1476-069X (2016) [Refereed Article]


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© 2016 The Author(s). Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/

DOI: doi:10.1186/s12940-016-0173-5

Abstract

Background: Children with asthma experience increased susceptibility to airborne pollutants. Exposure to traffic and industrial activity have been positively associated with exacerbation of symptoms as well as emergency room visits and hospitalisations. The effect of trace metals contained in fine particulate matter (aerodynamic diameter 2.5 μm and lower, PM2.5) on acute health effects amongst asthmatic children has not been well investigated. The objective of this panel study in asthmatic children was to determine the association between personal daily exposure to ambient trace metals and airway inflammation, as measured by fractional exhaled nitric oxide (FeNO).

Methods: Daily concentrations of trace metals contained on PM2.5 were determined from personal samples (n = 217) collected from 70 asthmatic school aged children in Montreal, Canada, over ten consecutive days. FeNO was measured daily using standard techniques.

Results: A positive association was found between FeNO and children’s exposure to an indicator of vehicular non-tailpipe emissions (8.9 % increase for an increase in the interquartile range (IQR) in barium, 95 % confidence interval (CI): 2.8, 15.4) as well as exposure to an indicator of industrial emissions (7.6 % increase per IQR increase in vanadium, 95 % CI: 0.1, 15.8). Elevated FeNO was also suggested for other metals on the day after the exposure: 10.3 % increase per IQR increase in aluminium (95 % CI: 4.2, 16.6) and 7.5 % increase per IQR increase in iron (95 % CI: 1.5, 13.9) at a 1-day lag period.

Conclusions: Exposures to ambient PM2.5 containing trace metals that are markers of traffic and industrial-derived emissions were associated in asthmatic children with an enhanced FeNO response.

Item Details

Item Type:Refereed Article
Keywords:Children, Air pollution, Trace metals, Exposure, Asthma, Lung inflammation, Exhaled nitric oxide, Urban environment, Petroleum refinery, Panel study, Particulate matter
Research Division:Medical and Health Sciences
Research Group:Public Health and Health Services
Research Field:Environmental and Occupational Health and Safety
Objective Division:Health
Objective Group:Public Health (excl. Specific Population Health)
Objective Field:Environmental Health
Author:Wheeler, AJ (Dr Amanda Wheeler)
ID Code:111413
Year Published:2016
Web of Science® Times Cited:2
Deposited By:Menzies Institute for Medical Research
Deposited On:2016-09-12
Last Modified:2017-11-02
Downloads:42 View Download Statistics

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