Lu, M and Chen, Z and Han, W and Zhu, Z and Jin, X and Hunter, DJ and Ding, C, A novel method for assessing signal intensity within infrapatellar fat pad on MR images in patients with knee osteoarthritis, Osteoarthritis and Cartilage, 24, (11) pp. 1883-1889. ISSN 1063-4584 (2016) [Refereed Article]
Copyright 2016 Osteoarthritis Research Society International
METHODS: Hundred patients with knee OA were selected. Sagittal planes of fat-saturated T2-weighted images obtained on 1.5-T magnetic resonance imaging (MRI) were utilized to assess IPFP signal intensity using MATLAB. Knee structural abnormalities including cartilage defects, bone marrow lesions (BML) and radiographic OA (ROA) were evaluated. Clinical construct validity and concurrent validity were examined through describing associations of IPFP measurements with knee structural abnormalities and a semi-quantitative scoring method, respectively. The reliability was examined by calculating the intra- and inter-observer correlation coefficients.
RESULTS: Significantly positive associations were found between standard deviation of IPFP signal intensity [sDev (IPFP)], clustering factor (H) and all knee structural abnormalities. The volume of high signal intensity regions [Volume (H)] and the ratio of Volume (H) to volume of whole IPFP [Percentage (H)] were positively associated with cartilage defects and ROA, but not with BMLs. The median value [Median (H)] and upper quartile value [UQ (H)] of high signal intensity were only significantly associated with quartiles of cartilage defect score. Significant correlations were found between all quantitative measurements and semi-quantitative scores (All P < 0.001). Intraclass and interclass correlation coefficients for these quantitative measures were high (>0.90).
CONCLUSIONS: A novel and efficient method to segment IPFP and calculate its signal intensity on T2-weighted MRI images is documented. This method is reproducible, and has concurrent and clinical construct validity, but its predictive validity needs to be examined by future longitudinal studies.
|Item Type:||Refereed Article|
|Keywords:||Osteoarthritis, Infrapatellar fat pad, High signal intensity, MR images|
|Research Division:||Medical and Health Sciences|
|Research Group:||Clinical Sciences|
|Research Field:||Rheumatology and Arthritis|
|Objective Group:||Clinical Health (Organs, Diseases and Abnormal Conditions)|
|Objective Field:||Skeletal System and Disorders (incl. Arthritis)|
|Author:||Lu, M (Dr Ming Lu)|
|Author:||Chen, Z (Dr Zhongshan Chen)|
|Author:||Han, W (Dr Weiyu Han)|
|Author:||Zhu, Z (Mr Zhaohua Zhu)|
|Author:||Jin, X (Mr Xingzhong Jin)|
|Author:||Ding, C (Professor Chang-Hai Ding)|
|Web of Science® Times Cited:||5|
|Deposited By:||Menzies Institute for Medical Research|
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