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A novel method for assessing signal intensity within infrapatellar fat pad on MR images in patients with knee osteoarthritis


Lu, M and Chen, Z and Han, W and Zhu, Z and Jin, X and Hunter, DJ and Ding, C, A novel method for assessing signal intensity within infrapatellar fat pad on MR images in patients with knee osteoarthritis, Osteoarthritis and Cartilage, 24, (11) pp. 1883-1889. ISSN 1063-4584 (2016) [Refereed Article]

Copyright Statement

Copyright 2016 Osteoarthritis Research Society International

DOI: doi:10.1016/j.joca.2016.06.008


PURPOSE: To assess reliability and validity of a semi-automated quantitative method to measure infrapatellar fat pad (IPFP) signal intensity in patients with knee osteoarthritis (OA).

METHODS: Hundred patients with knee OA were selected. Sagittal planes of fat-saturated T2-weighted images obtained on 1.5-T magnetic resonance imaging (MRI) were utilized to assess IPFP signal intensity using MATLAB. Knee structural abnormalities including cartilage defects, bone marrow lesions (BML) and radiographic OA (ROA) were evaluated. Clinical construct validity and concurrent validity were examined through describing associations of IPFP measurements with knee structural abnormalities and a semi-quantitative scoring method, respectively. The reliability was examined by calculating the intra- and inter-observer correlation coefficients.

RESULTS: Significantly positive associations were found between standard deviation of IPFP signal intensity [sDev (IPFP)], clustering factor (H) and all knee structural abnormalities. The volume of high signal intensity regions [Volume (H)] and the ratio of Volume (H) to volume of whole IPFP [Percentage (H)] were positively associated with cartilage defects and ROA, but not with BMLs. The median value [Median (H)] and upper quartile value [UQ (H)] of high signal intensity were only significantly associated with quartiles of cartilage defect score. Significant correlations were found between all quantitative measurements and semi-quantitative scores (All P < 0.001). Intraclass and interclass correlation coefficients for these quantitative measures were high (>0.90).

CONCLUSIONS: A novel and efficient method to segment IPFP and calculate its signal intensity on T2-weighted MRI images is documented. This method is reproducible, and has concurrent and clinical construct validity, but its predictive validity needs to be examined by future longitudinal studies.

Item Details

Item Type:Refereed Article
Keywords:Osteoarthritis, Infrapatellar fat pad, High signal intensity, MR images
Research Division:Biomedical and Clinical Sciences
Research Group:Clinical sciences
Research Field:Rheumatology and arthritis
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Lu, M (Dr Ming Lu)
UTAS Author:Chen, Z (Dr Zhongshan Chen)
UTAS Author:Han, W (Dr Weiyu Han)
UTAS Author:Zhu, Z (Mr Zhaohua Zhu)
UTAS Author:Jin, X (Mr Xingzhong Jin)
UTAS Author:Ding, C (Professor Chang-Hai Ding)
ID Code:111358
Year Published:2016
Web of Science® Times Cited:17
Deposited By:Menzies Institute for Medical Research
Deposited On:2016-09-08
Last Modified:2017-11-01

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